Publications by the researcher in collaboration with J. Egea (23)

2019

  1. Nrf2 plays a protective role against intravascular hemolysis-mediated acute kidney injury

    Frontiers in Pharmacology, Vol. 10

2017

  1. ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels

    Neurochemical Research, Vol. 42, Núm. 2, pp. 347-359

  2. Enzymatic and solid-phase synthesis of new donepezil-based L- and D-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

    European Journal of Medicinal Chemistry, Vol. 130, pp. 60-72

2016

  1. Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

    Pharmacology and Therapeutics, Vol. 157, pp. 84-104

  2. Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures

    Molecular Neurobiology, Vol. 53, Núm. 5, pp. 3338-3348

  3. The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

    Journal of Medicinal Chemistry, Vol. 59, Núm. 21, pp. 9967-9973

2015

  1. Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase i induction

    Biochemical Pharmacology, Vol. 97, Núm. 4, pp. 473-481

  2. Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

    Biochemical Pharmacology, Vol. 97, Núm. 4, pp. 463-472

  3. Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action

    British Journal of Pharmacology, Vol. 172, Núm. 7, pp. 1807-1821

  4. Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models

    Neuropharmacology, Vol. 99, pp. 187-195

  5. New melatonin-cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection

    Future Medicinal Chemistry, Vol. 7, Núm. 15, pp. 1961-1969

  6. The melatonin- N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction

    ACS Chemical Neuroscience, Vol. 6, Núm. 2, pp. 288-296

2014

  1. Neuroprotective effect of dimebon against ischemic neuronal damage

    Neuroscience, Vol. 267, pp. 11-21

  2. Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

    Journal of Pineal Research, Vol. 56, Núm. 2, pp. 204-212

  3. New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury

    Journal of Medicinal Chemistry, Vol. 57, Núm. 10, pp. 4313-4323

2013

  1. Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents

    MedChemComm, Vol. 4, Núm. 3, pp. 590-594

  2. Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

    Neuropharmacology, Vol. 67, pp. 403-411

2012

  1. Benzothiazepine CGP37157 and its isosteric 2′-ethyl analogue provide neuroprotection and block cell calcium entry

    ACS Chemical Neuroscience, Vol. 3, Núm. 7, pp. 519-529

2011

  1. Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release

    British Journal of Pharmacology, Vol. 162, Núm. 1, pp. 94-110

  2. N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235