Publications in collaboration with researchers from Instituto de Química Orgánica General (17)

2017

  1. Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices

    Neuropharmacology, Vol. 116, pp. 110-121

2016

  1. The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

    Journal of Medicinal Chemistry, Vol. 59, Núm. 21, pp. 9967-9973

2013

  1. Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

    Medicinal Research Reviews, Vol. 33, Núm. 1, pp. 139-189

2011

  1. A step further towards multitarget drugs for Alzheimer and neuronal vascular diseases: Targeting the cholinergic system, amyloid-β aggregation and Ca2+dyshomeostasis

    Current Medicinal Chemistry, Vol. 18, Núm. 4, pp. 552-576

  2. Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6119-6130

2010

  1. Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

    Journal of Medicinal Chemistry, Vol. 53, Núm. 14, pp. 5129-5143

2009

  1. A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines

    Molecular Diversity, Vol. 13, Núm. 4, pp. 459-468

  2. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease

    Journal of Medicinal Chemistry, Vol. 52, Núm. 9, pp. 2724-2732

2008

  1. New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 16, pp. 7759-7769

  2. Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death

    European Journal of Medicinal Chemistry, Vol. 43, Núm. 3, pp. 668-674

2006

  1. New multipotent tetracyclic tacrines with neuroprotective activity

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 24, pp. 8176-8185

  2. Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease

    Journal of Medicinal Chemistry, Vol. 49, Núm. 26, pp. 7607-7610

  3. Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals

    European Journal of Medicinal Chemistry, Vol. 41, Núm. 12, pp. 1464-1469

  4. Unexpected results in the Friedländer reaction of 4-aryl-7,7-dimethyl- 5-oxo-5,6,7,8-tetrahydro-4H-[1]benzopyran-3-carbonitriles

    Journal of Chemical Research, pp. 536-538

2005

  1. 1,6-C-H and 1,5-O-Si insertion reactions of alkylidenecarbene derivatives of monosaccharides

    Journal of Carbohydrate Chemistry, Vol. 24, Núm. 4-6, pp. 369-377

  2. Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues

    Bioorganic and Medicinal Chemistry, Vol. 13, Núm. 4, pp. 1167-1175

2004

  1. ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8] naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties

    Journal of Pharmacology and Experimental Therapeutics, Vol. 310, Núm. 3, pp. 987-994