RAFAEL
LEÓN MARTÍNEZ
Profesor asociado
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Instituto de Química Médica
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Instituto de Química Médica (19)
2024
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Innovative pathological network-based multitarget approaches for Alzheimer's disease treatment
Medicinal Research Reviews
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TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation
EMBO Journal, Vol. 43, Núm. 13, pp. 2789-2812
2023
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KEAP1-NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
Medicinal Research Reviews, Vol. 43, Núm. 1, pp. 237-287
2022
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Curcumin-piperlongumine hybrids with a multitarget profile elicit neuroprotection in in vitro models of oxidative stress and hyperphosphorylation
Antioxidants, Vol. 11, Núm. 1
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Enantioselective Synthesis and Pharmacological Evaluation of Aza‐CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease
Antioxidants, Vol. 11, Núm. 1
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Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
Antioxidants, Vol. 11, Núm. 2
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Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Journal of Medicinal Chemistry, Vol. 65, Núm. 6, pp. 4727-4751
2021
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Bisavenathramide analogues as nrf2 inductors and neuroprotectors in in vitro models of oxidative stress and hyperphosphorylation
Antioxidants, Vol. 10, Núm. 6
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Enhanced stability and bioactivity of natural anticancer topoisomerase i inhibitors through cyclodextrin complexation
Pharmaceutics, Vol. 13, Núm. 10
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Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches
Handbook of Experimental Pharmacology (Springer Science and Business Media Deutschland GmbH), pp. 229-259
2020
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Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties
European Journal of Medicinal Chemistry, Vol. 190
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When it comes to an end: Oxidative stress crosstalk with protein aggregation and neuroinflammation induce neurodegeneration
Antioxidants, Vol. 9, Núm. 8, pp. 1-34
2017
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Enzymatic and solid-phase synthesis of new donepezil-based L- and D-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia
European Journal of Medicinal Chemistry, Vol. 130, pp. 60-72
2015
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The melatonin- N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction
ACS Chemical Neuroscience, Vol. 6, Núm. 2, pp. 288-296
2013
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Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia
Neuropharmacology, Vol. 67, pp. 403-411
2012
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Benzothiazepine CGP37157 and its isosteric 2′-ethyl analogue provide neuroprotection and block cell calcium entry
ACS Chemical Neuroscience, Vol. 3, Núm. 7, pp. 519-529
2011
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N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235
2009
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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease
Journal of Medicinal Chemistry, Vol. 52, Núm. 9, pp. 2724-2732
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The N-terminal tripeptide of insulin-like growth factor-I protects against β-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3β modulation
Journal of Neurochemistry, Vol. 109, Núm. 2, pp. 360-370