Instituto de Química Médica -ko ikertzaileekin lankidetzan egindako argitalpenak (13)

2023

  1. Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

    Journal of Medicinal Chemistry, Vol. 66, Núm. 19, pp. 13452-13480

2022

  1. 5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents

    Acta Tropica, Vol. 234

2021

  1. Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles

    Bioorganic and Medicinal Chemistry Letters, Vol. 37

2020

  1. Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi y strain (DTU TcII): In vitro and in vivo studies

    Parasitology, Vol. 147, Núm. 11, pp. 1216-1228

2018

  1. Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines

    ChemMedChem, Vol. 13, Núm. 12, pp. 1246-1259

  2. Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi

    Parasitology Research, Vol. 117, Núm. 11, pp. 3367-3380

2017

  1. New imidazole-based compounds active against Trypanosoma cruzi

    Combinatorial Chemistry and High Throughput Screening, Vol. 20, Núm. 1, pp. 20-24

  2. Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties

    European Journal of Medicinal Chemistry, Vol. 136, pp. 223-234

2016

  1. Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles

    European Journal of Medicinal Chemistry, Vol. 115, pp. 295-310

  2. Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes

    Parasitology, Vol. 143, Núm. 11, pp. 1469-1478

2015

  1. Novel solid dispersions of benznidazole: Preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system

    Experimental Parasitology, Vol. 149, pp. 84-91

2014

  1. Development of novel benznidazole formulations: Physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease

    International Journal of Pharmaceutics, Vol. 472, Núm. 1-2, pp. 110-117

2012

  1. Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug

    European Journal of Medicinal Chemistry, Vol. 58, pp. 214-227