ALICIA
GÓMEZ BARRIO
Catedrática de universidad
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Instituto de Química Médica
Madrid, EspañaPublikationen in Zusammenarbeit mit Forschern von Instituto de Química Médica (42)
2023
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Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites
Journal of Medicinal Chemistry, Vol. 66, Núm. 19, pp. 13452-13480
2022
2021
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Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles
Bioorganic and Medicinal Chemistry Letters, Vol. 37
2020
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Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi y strain (DTU TcII): In vitro and in vivo studies
Parasitology, Vol. 147, Núm. 11, pp. 1216-1228
2018
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Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines
ChemMedChem, Vol. 13, Núm. 12, pp. 1246-1259
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Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening
Future Medicinal Chemistry, Vol. 10, Núm. 8, pp. 863-878
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Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi
Parasitology Research, Vol. 117, Núm. 11, pp. 3367-3380
2017
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New imidazole-based compounds active against Trypanosoma cruzi
Combinatorial Chemistry and High Throughput Screening, Vol. 20, Núm. 1, pp. 20-24
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Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties
European Journal of Medicinal Chemistry, Vol. 136, pp. 223-234
2016
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Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles
European Journal of Medicinal Chemistry, Vol. 115, pp. 295-310
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Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes
Parasitology, Vol. 143, Núm. 11, pp. 1469-1478
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In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives
Parasitology, Vol. 143, Núm. 1, pp. 34-40
2015
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Novel solid dispersions of benznidazole: Preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system
Experimental Parasitology, Vol. 149, pp. 84-91
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Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents
European Journal of Medicinal Chemistry, Vol. 94, pp. 276-283
2014
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A sequential procedure for rapid and accurate identification of putative trichomonacidal agents
Journal of Microbiological Methods, Vol. 105, pp. 162-167
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Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones
Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 5, pp. 1568-1585
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Determination of internal transcribed spacer regions (ITS) in Trichomonas vaginalis isolates and differentiation among Trichomonas species
Parasitology International, Vol. 63, Núm. 2, pp. 427-431
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Development of novel benznidazole formulations: Physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease
International Journal of Pharmaceutics, Vol. 472, Núm. 1-2, pp. 110-117
2012
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Descubrimiento de nuevos antimaláricos a partir de fármacos conocidos mediante cribado in silico e in vitro
Anales de la Real Academia Nacional de Farmacia, Vol. 78, Núm. 4, pp. 401-416
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Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
European Journal of Medicinal Chemistry, Vol. 58, pp. 214-227