Publicaciones (24) Publicaciones de MACARENA HERNÁNDEZ JIMÉNEZ

2023

  1. APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke

    Frontiers in Neurology, Vol. 14

  2. Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction

    Biomedicine and Pharmacotherapy, Vol. 158

  3. Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice

    Frontiers in Cellular Neuroscience, Vol. 17

  4. Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations

    Stroke, Vol. 54, Núm. 10, pp. 2698-2707

  5. Safety and Efficacy of ApTOLL in Patients with Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial

    JAMA Neurology, Vol. 80, Núm. 8, pp. 779-788

2022

  1. First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

    Molecular Therapy - Nucleic Acids, Vol. 28, pp. 124-135

2021

  1. Defining a Target Population to Effectively Test a Neuroprotective Drug

    Stroke, Vol. 52, Núm. 2, pp. 505-510

  2. Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI

    Journal of Cerebral Blood Flow and Metabolism, Vol. 41, Núm. 7, pp. 1692-1706

2020

  1. Targeting tlr4 with aptoll improves heart function in response to coronary ischemia reperfusion in pigs undergoing acute myocardial infarction

    Biomolecules, Vol. 10, Núm. 8, pp. 1-13

2019

  1. Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance

    Stroke, Vol. 50, Núm. 11, pp. 3228-3237

2018

  1. TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

    Molecular Therapy, Vol. 26, Núm. 8, pp. 2047-2059

2017

  1. Test repositioning for functional assessment of neurological outcome after experimental stroke in mice

    PLoS ONE, Vol. 12, Núm. 5

2016

  1. Seladin-1/DHCR24 is neuroprotective by associating EAAT2 glutamate transporter to lipid rafts in experimental stroke

    Stroke, Vol. 47, Núm. 1, pp. 206-213

2015

  1. Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia

    Journal of Neuroinflammation, Vol. 12, Núm. 1, pp. 1

  2. Animal Models of tPA-Induced Hemorrhagic Transformation

    Rational Basis for Clinical Translation in Stroke Therapy (CRC Press. Taylor & Francis Group), pp. 299-310

2014

  1. Animal Models of t-PA-Induced Hemorrhagic Transformation

    Rational Basis for Clinical Translation in Stroke Therapy (CRC Press), pp. 299-310

  2. Apoptosis-related proteins are potential markers of neonatal hypoxic-ischemic encephalopathy (HIE) injury

    Neuroscience Letters, Vol. 558, pp. 143-148

  3. Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia

    FASEB Journal, Vol. 28, Núm. 11, pp. 4710-4718

2013

  1. Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke

    Journal of Neurochemistry, Vol. 126, Núm. 6, pp. 819-826

  2. Silent information regulator 1 protects the brain against cerebral ischemic damage

    Stroke, Vol. 44, Núm. 8, pp. 2333-2337