AGUSTÍN
TORTAJADA ALONSO
Profesor ayudante doctor
Publicaciones (30) Publicaciones de AGUSTÍN TORTAJADA ALONSO
2022
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Activation of the unfolded protein response (Upr) is associated with cholangiocellular injury, fibrosis and carcinogenesis in an experimental model of fibropolycystic liver disease
Cancers, Vol. 14, Núm. 1
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Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy
Journal of the American Society of Nephrology : JASN, Vol. 33, Núm. 6, pp. 1137-1153
2019
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The role of complement in IgA nephropathy
Molecular Immunology, Vol. 114, pp. 123-132
2018
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Complete functional characterization of disease-associated genetic variants in the complement factor H gene
Kidney International, Vol. 93, Núm. 2, pp. 470-481
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Factor H competitor generated by gene conversion events associates with atypical hemolytic uremic syndrome
Journal of the American Society of Nephrology, Vol. 29, Núm. 1, pp. 240-249
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How novel structures inform understanding of complement function
Seminars in Immunopathology, Vol. 40, Núm. 1, pp. 3-14
2017
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Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy
Kidney International, Vol. 92, Núm. 4, pp. 953-963
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FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation
Journal of Immunology, Vol. 199, Núm. 1, pp. 292-303
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Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications
European Journal of Immunology, Vol. 47, Núm. 3, pp. 504-515
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Interaction between multimeric von willebrand factor and complement: A fresh look to the pathophysiology of microvascular thrombosis
Journal of Immunology, Vol. 199, Núm. 3, pp. 1021-1040
2016
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Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion gene
Molecular Immunology, Vol. 77, pp. 89-96
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Molecular basis of factor H R1210C association with ocular and renal diseases
Journal of the American Society of Nephrology, Vol. 27, Núm. 5, pp. 1305-1311
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Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy
Clinical and Experimental Immunology, Vol. 184, Núm. 1, pp. 118-125
2015
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A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation
Journal of the American Society of Nephrology, Vol. 26, Núm. 1, pp. 209-219
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Factor H-related proteins determine complement-activating surfaces
Trends in Immunology, Vol. 36, Núm. 6, pp. 374-384
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The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome
Molecular Immunology, Vol. 66, Núm. 2, pp. 263-273
2014
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A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models
Journal of Immunology, Vol. 193, Núm. 11, pp. 5567-5575
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Genetics of atypical hemolytic uremic syndrome (aHUS)
Seminars in Thrombosis and Hemostasis, Vol. 40, Núm. 4, pp. 422-430
2013
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C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation
Journal of Clinical Investigation, Vol. 123, Núm. 6, pp. 2434-2446
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Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin
Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Núm. 33, pp. 13504-13509