Publications in collaboration with researchers from Instituto de Química Médica (23)

2024

  1. Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties

    European Journal of Medicinal Chemistry, Vol. 277

2022

  1. Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

    Journal of Medicinal Chemistry, Vol. 65, Núm. 6, pp. 4727-4751

2020

  1. Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

    European Journal of Medicinal Chemistry, Vol. 190

2019

  1. New flavonoid–N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 712-727

2018

  1. Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 156, pp. 534-553

2017

  1. Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

    Journal of Medicinal Chemistry, Vol. 60, Núm. 12, pp. 4983-5001

  2. The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

    Scientific Reports, Vol. 7, Núm. 1

2016

  1. New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

    European Journal of Medicinal Chemistry, Vol. 121, pp. 376-386

  2. New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition

    Future Medicinal Chemistry, Vol. 8, Núm. 11, pp. 1191-1207

2015

  1. Neurogenic potential assessment and pharmacological characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids

    ACS Chemical Neuroscience, Vol. 6, Núm. 5, pp. 800-810

  2. Novel N -Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential

    Journal of Medicinal Chemistry, Vol. 58, Núm. 12, pp. 4998-5014

  3. PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

    British Journal of Pharmacology, Vol. 172, Núm. 17, pp. 4277-4290

2014

  1. Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: Two relevant therapeutic targets for neurological disorders

    ACS Chemical Neuroscience, Vol. 5, Núm. 3, pp. 194-204

  2. Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors

    Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607

  3. New melatonin- N, N -dibenzyl(N -methyl)amine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for alzheimers disease

    Journal of Medicinal Chemistry, Vol. 57, Núm. 9, pp. 3773-3785

2013

  1. Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

    ACS Chemical Neuroscience, Vol. 4, Núm. 2, pp. 350-360

2012

  1. 5-Imino-1,2,4-thiadiazoles: First small molecules As substrate competitive inhibitors of glycogen synthase kinase 3

    Journal of Medicinal Chemistry, Vol. 55, Núm. 4, pp. 1645-1661

  2. Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

    Journal of Medicinal Chemistry, Vol. 55, Núm. 7, pp. 3274-3284

  3. Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo

    ACS Chemical Neuroscience, Vol. 3, Núm. 11, pp. 963-971

  4. Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

    European Journal of Medicinal Chemistry, Vol. 58, pp. 44-49