Publikationen (64) Publikationen von JAVIER DEL PINO SANS

2024

  1. Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells

    Food and Chemical Toxicology, Vol. 193

  2. Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment

    Foods, Vol. 13, Núm. 15

2023

  1. Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo

    Biology, Vol. 12, Núm. 6

  2. Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain

    Chemico-Biological Interactions, Vol. 375

  3. Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools

    Pharmaceutics, Vol. 15, Núm. 8

2022

  1. Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption

    Environmental Toxicology and Pharmacology, Vol. 90

  2. Insulin Signaling Disruption and INF-γUpregulation Induce Aβ1-42and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells

    Chemical Research in Toxicology, Vol. 35, Núm. 12, pp. 2214-2218

  3. Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation

    Food and Chemical Toxicology, Vol. 167

  4. Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death

    Food and Chemical Toxicology, Vol. 170

2021

  1. Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/β-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment

    Chemical Research in Toxicology, Vol. 34, Núm. 9, pp. 2019-2023

  2. Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75NTR signaling disruption

    Food and Chemical Toxicology, Vol. 157

  3. Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/β-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment

    Food and Chemical Toxicology, Vol. 152

  4. Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity

    European Journal of Medicinal Chemistry, Vol. 210

  5. Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells

    ACS Chemical Neuroscience, Vol. 12, Núm. 18, pp. 3358-3372

  6. Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption

    Chemical Research in Toxicology, Vol. 34, Núm. 5, pp. 1240-1244

2020

  1. Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure

    Chemosphere, Vol. 251

  2. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment

    Food and Chemical Toxicology, Vol. 144

  3. Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment

    Ecotoxicology and Environmental Safety, Vol. 203

  4. Primary hippocampal estrogenic dysfunction induces synaptic proteins alteration and neuronal cell death after single and repeated paraquat exposure

    Food and Chemical Toxicology, Vol. 136

2019

  1. Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment

    Food and Chemical Toxicology, Vol. 125, pp. 583-594