JOSÉ LUIS
MARCO CONTELLES
Investigador en el periodo 2018-2019
Hospital Universitario de la Princesa
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Hospital Universitario de la Princesa (38)
2022
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Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment
Antioxidants, Vol. 11, Núm. 9
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Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout
Journal of Medicinal Chemistry, Vol. 65, Núm. 8, pp. 6250-6260
2021
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(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
ACS Chemical Neuroscience, Vol. 12, Núm. 8, pp. 1328-1342
2020
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In Vitro and in Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
ACS Chemical Neuroscience, Vol. 11, Núm. 22, pp. 3793-3801
2019
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New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
Journal of Medicinal Chemistry, Vol. 62, Núm. 24, pp. 11416-11422
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Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy
Molecules, Vol. 24, Núm. 8
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Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines
European Journal of Medicinal Chemistry, Vol. 166, pp. 381-389
2018
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Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine
Future Medicinal Chemistry, Vol. 10, Núm. 11, pp. 1289-1300
2017
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Ischemic brain injury: New insights on the protective role of melatonin
Free Radical Biology and Medicine, Vol. 104, pp. 32-53
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Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration
Future Medicinal Chemistry, Vol. 9, Núm. 8, pp. 765-780
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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
Angewandte Chemie - International Edition, Vol. 56, Núm. 41, pp. 12765-12769
2016
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Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices
NeuroToxicology, Vol. 57, pp. 61-68
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The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Journal of Medicinal Chemistry, Vol. 59, Núm. 21, pp. 9967-9973
2013
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Enantioselective neuroprotective effects of tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices
CNS Neuroscience and Therapeutics
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PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice
ACS Chemical Neuroscience, Vol. 4, Núm. 9, pp. 1267-1277
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Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
Medicinal Research Reviews, Vol. 33, Núm. 1, pp. 139-189
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Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-β-induced neurotoxicity
ACS Chemical Neuroscience, Vol. 4, Núm. 4, pp. 547-565
2012
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Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
European Journal of Medicinal Chemistry, Vol. 52, pp. 251-262
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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 54, pp. 750-763
2011
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Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity
European Journal of Pharmacology, Vol. 660, Núm. 2-3, pp. 411-419