Publicaciones en colaboración con investigadores/as de Instituto de Química Médica (21)

2019

  1. Acid-base behaviour and binding to double stranded DNA/RNA of benzo[g]phthalazine-based ligands

    New Journal of Chemistry, Vol. 43, Núm. 2, pp. 700-708

2015

  1. Imidazole-containing phthalazine derivatives inhibit Fe-SOD performance in Leishmania species and are active in vitro against visceral and mucosal leishmaniasis

    Parasitology, Vol. 142, Núm. 8, pp. 1115-1129

  2. Synthesis and evaluation of in vitro and in vivo trypanocidal properties of a new imidazole-containing nitrophthalazine derivative

    European Journal of Medicinal Chemistry, Vol. 106, pp. 106-119

2012

  1. In vitro leishmanicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against leishmania infantum and leishmania braziliensis species

    Journal of Antimicrobial Chemotherapy, Vol. 67, Núm. 2, pp. 387-397

  2. Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection

    Journal of Medicinal Chemistry, Vol. 55, Núm. 22, pp. 9900-9913

2011

  1. In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[ g ]phthalazine derivatives against acute and chronic phases of chagas disease

    Journal of Medicinal Chemistry, Vol. 54, Núm. 4, pp. 970-979

2010

  1. Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 14, pp. 5301-5309

2008

  1. Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings

    Journal of Medicinal Chemistry, Vol. 51, Núm. 6, pp. 1962-1966

2007

  1. 1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi

    Bioorganic and Medicinal Chemistry, Vol. 15, Núm. 5, pp. 2081-2091

2005

  1. New acyclic receptors containing pyridazine units. The influence of π-stacking on the selective transport of lipophilic phenethylamines

    Tetrahedron, Vol. 61, Núm. 50, pp. 11965-11975

2004

  1. A new series of heteroaromatic receptors containing the 1,3-bis(6-oxopyridazin-1-yl)propane unit: Their selective transport ability towards NH4+ in relation to Na+, K+ and Ca2+

    Tetrahedron, Vol. 60, Núm. 4, pp. 979-986

1997

  1. A proton-ionizable ester crown of 3,5-disubstituted 1H-pyrazole able to form stable dinuclear complexes with lipophilic phenethylamines

    Journal of Organic Chemistry, Vol. 62, Núm. 9, pp. 2684-2693

1994

  1. Formation of mono- and di- nuclear complexes of Zn2+ from a 26 membered tetraester crown of 3,5-disubstituted pyrazole able to act as neutral and dianionic ligand

    Tetrahedron, Vol. 50, Núm. 16, pp. 4765-4774

  2. The action of the DNA intercalating agents 4′-(9-acridinylamino) methanesulphon-m-anisidide and 1,4-bis(butylamino) benzo[G]phthalazine in U-937 human promonocytic cells: Relationship between cell cycle and differentiation

    Biochemical Pharmacology, Vol. 48, Núm. 1, pp. 72-82

1993

  1. Synthesis of a stable dinuclear complex formed from a 26 membered proton-ionizable crown of 3,5-disusbstituted 1H-pyrazole and homoveratrylamine

    Tetrahedron Letters, Vol. 34, Núm. 45, pp. 7299-7300

1992

  1. Synthesis of Alkylamino Derivatives of l94,69ll-Tetrahydropyridazino[l,2-6]phthalazine-641-dione

    Chemical and Pharmaceutical Bulletin, Vol. 40, Núm. 11, pp. 2905-2908

1991

  1. A New Ionizable Chromophore of 1,4-Bis(alkylamino)benzo[g]phthalazine Which Interacts with DNA by Intercalation

    Journal of Medicinal Chemistry, Vol. 34, Núm. 1, pp. 82-86

1987

  1. Diazapolycyclic compounds. XXVII. On the selective hydrogenation of benzo[g]phthalazine‐1,4‐dione and 5‐methoxybenzo[g]phthalazine‐1,4‐dione adducts

    Journal of Heterocyclic Chemistry, Vol. 24, Núm. 4, pp. 981-987

  2. Protonation of 1,4-bis(alkylamino)benzo[g]phthalazine. Crystal structure of di(1,4-bis-(3-methoxypropylamino)-3(2)H-benzo[g]phthalazinium) tetrachlorocobaltate monohydrate

    Journal of the Chemical Society, Perkin Transactions 2, pp. 569-573

1986

  1. Synthesis and cytostatic activity of 1,4-bis-(alkylamino) benzo(g)phthalazines with complexing properties

    European Journal of Medicinal Chemistry, Vol. 21, Núm. 2, pp. 143-149