PATRYCJA
MICHALSKA DZIAMA
Profesora ayudante doctora
Hospital Universitario de la Princesa
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Hospital Universitario de la Princesa (22)
2022
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Enantioselective Synthesis and Pharmacological Evaluation of Aza‐CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease
Antioxidants, Vol. 11, Núm. 1
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Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
Antioxidants, Vol. 11, Núm. 2
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Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Journal of Medicinal Chemistry, Vol. 65, Núm. 6, pp. 4727-4751
2020
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Antioxidant, anti-inflammatory and neuroprotective profiles of novel 1,4-dihydropyridine derivatives for the treatment of alzheimer’s disease
Antioxidants, Vol. 9, Núm. 8, pp. 1-20
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Aza-CGP37157-lipoic hybrids designed as novel Nrf2-inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties
Drug Development Research, Vol. 81, Núm. 3, pp. 283-294
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Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization
Pharmacological Research, Vol. 152
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New Nrf2-inducer compound ITH12674 slows the progression of retinitis pigmentosa in the mouse model rd10
Cellular Physiology and Biochemistry, Vol. 54, Núm. 1, pp. 142-159
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Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties
European Journal of Medicinal Chemistry, Vol. 190
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When it comes to an end: Oxidative stress crosstalk with protein aggregation and neuroinflammation induce neurodegeneration
Antioxidants, Vol. 9, Núm. 8, pp. 1-34
2019
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Nrf2 plays a protective role against intravascular hemolysis-mediated acute kidney injury
Frontiers in Pharmacology, Vol. 10
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Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux
Journal of Pineal Research, Vol. 67, Núm. 1
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The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
Aging Cell, Vol. 18, Núm. 3
2018
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MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species
Translational Research, Vol. 200, pp. 1-17
2017
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Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease
Scientific Reports, Vol. 7
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ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia
ACS Chemical Neuroscience, Vol. 8, Núm. 1, pp. 67-81
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Inclusion complex of ITH12674 with 2-hydroxypropyl-β-cyclodextrin: Preparation, physical characterization and pharmacological effect
Carbohydrate Polymers, Vol. 157, pp. 94-104
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Novel multitarget hybrid compounds for the treatment of alzheimer’s disease
Current Topics in Medicinal Chemistry, Vol. 17, Núm. 9, pp. 1027-1043
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Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices
Neuropharmacology, Vol. 116, pp. 110-121
2016
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Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
Pharmacology and Therapeutics, Vol. 157, pp. 84-104
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The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Journal of Medicinal Chemistry, Vol. 59, Núm. 21, pp. 9967-9973