Bioquímica y Biología Molecular
Departamento
SILVIA
ORTEGA GUTIÉRREZ
Catedrática de universidad
Publicaciones en las que colabora con SILVIA ORTEGA GUTIÉRREZ (23)
2021
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Chemistry for the Identification of Therapeutic Targets: Recent Advances and Future Directions
European Journal of Organic Chemistry, Vol. 2021, Núm. 9, pp. 1307-1320
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Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome
ACS Central Science, Vol. 7, Núm. 8, pp. 1300-1310
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Small-molecule therapeutic perspectives for the treatment of progeria
International Journal of Molecular Sciences, Vol. 22, Núm. 13
2019
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A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia
Journal of Medicinal Chemistry, Vol. 62, Núm. 13, pp. 6035-6046
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Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons
Neuropharmacology, Vol. 150, pp. 134-144
2018
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Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-HT
1A
Receptor in Native Cells of the Immune System
Bioconjugate Chemistry, Vol. 29, Núm. 6, pp. 2021-2027
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A Fluorescent Probe to Unravel Functional Features of Cannabinoid Receptor CB1 in Human Blood and Tonsil Immune System Cells
Bioconjugate Chemistry, Vol. 29, Núm. 2, pp. 382-389
2016
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A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease
Journal of Neurology, Vol. 263, Núm. 7, pp. 1390-1400
2015
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New inhibitors of angiogenesis with antitumor activity in vivo
Journal of Medicinal Chemistry, Vol. 58, Núm. 9, pp. 3757-3766
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Role of cannabinoid receptor CB<inf>2</inf> in HER2 pro-oncogenic signaling in breast cancer
Journal of the National Cancer Institute, Vol. 107, Núm. 6
2014
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The expression of cannabinoid receptor 1 is significantly increased in atopic patients
Journal of Allergy and Clinical Immunology, Vol. 133, Núm. 3
2013
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The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system
International Journal of Neuropsychopharmacology, Vol. 16, Núm. 6, pp. 1407-1419
2007
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Neurochemical effects of the endocannabinoid uptake inhibitor UCM707 in various rat brain regions
Life Sciences, Vol. 80, Núm. 10, pp. 979-988
2006
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UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders
European Neuropsychopharmacology, Vol. 16, Núm. 1, pp. 7-18
2005
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Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels
Biochemical Pharmacology, Vol. 70, Núm. 3, pp. 446-452
2004
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Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: Synthesis of new transporter inhibitors as tools for this study
British Journal of Pharmacology, Vol. 141, Núm. 3, pp. 457-467
2003
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Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors
European Journal of Medicinal Chemistry
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Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: Comparison with effects on fatty acid amidohydrolase
Journal of Medicinal Chemistry, Vol. 46, Núm. 8, pp. 1512-1522
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Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 18, Núm. 3, pp. 225-231
2002
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Endocannabinoid transporter inhibitors
Current Medicinal Chemistry - Central Nervous System Agents, Vol. 2, Núm. 2, pp. 129-141