Microbiología y Parasitología
Departamento
Universidad Central de Las Villas
Santa Clara, CubaPublicaciones en colaboración con investigadores/as de Universidad Central de Las Villas (25)
2018
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Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines
ChemMedChem, Vol. 13, Núm. 12, pp. 1246-1259
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Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening
Future Medicinal Chemistry, Vol. 10, Núm. 8, pp. 863-878
2015
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Bond-based bilinear indices for computational discovery of novel trypanosomicidal drug-like compounds through virtual screening
European Journal of Medicinal Chemistry, Vol. 96, pp. 238-244
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Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents
European Journal of Medicinal Chemistry, Vol. 94, pp. 276-283
2014
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A sequential procedure for rapid and accurate identification of putative trichomonacidal agents
Journal of Microbiological Methods, Vol. 105, pp. 162-167
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Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones
Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 5, pp. 1568-1585
2012
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A fluorometric method for evaluation of pharmacological activity against intracellular Leishmania amastigotes
Journal of Microbiological Methods, Vol. 89, Núm. 1, pp. 8-11
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Identification In Silico and In Vitro of Novel Trypanosomicidal Drug-Like Compounds
Chemical Biology and Drug Design, Vol. 80, Núm. 1, pp. 38-45
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Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug
European Journal of Medicinal Chemistry, Vol. 58, pp. 214-227
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Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs
Memorias do Instituto Oswaldo Cruz, Vol. 107, Núm. 5, pp. 637-643
2011
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Ligand-based discovery of novel trypanosomicidal drug-like compounds: In silico identification and experimental support
European Journal of Medicinal Chemistry, Vol. 46, Núm. 8, pp. 3324-3330
2010
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Computational discovery of novel trypanosomicidal drug-like chemicals by using bond-based non-stochastic and stochastic quadratic maps and linear discriminant analysis
European Journal of Pharmaceutical Sciences, Vol. 39, Núm. 1-3, pp. 30-36
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QSAR for RNases and theoretic-experimental study of molecular diversity on peptide mass fingerprints of a new Leishmania infantum protein
Molecular Diversity, Vol. 14, Núm. 2, pp. 349-369
2009
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Discovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors
QSAR and Combinatorial Science, Vol. 28, Núm. 1, pp. 9-26
2008
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Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: In silico, in vitro and in vivo activity studies
European Journal of Medicinal Chemistry, Vol. 43, Núm. 9, pp. 1797-1807
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Bond-based linear indices in QSAR: Computational discovery of novel anti-trichomonal compounds
Journal of Computer-Aided Molecular Design, Vol. 22, Núm. 8, pp. 523-540
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HP-Lattice QSAR for dynein proteins: Experimental proteomics (2D-electrophoresis, mass spectrometry) and theoretic study of a Leishmania infantum sequence
Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 16, pp. 7770-7776
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New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors
Journal of Biomolecular Screening, Vol. 13, Núm. 8, pp. 785-794
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Saponinas esteroidales de la planta Agave brittoniana (Agavaceae) con actividad contra el parásito Trichomona vaginalis
Revista de Biologia Tropical, Vol. 56, Núm. 4, pp. 1645-1652
2006
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New ligand-based approach for the discovery of antitrypanosomal compounds
Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 7, pp. 1898-1904