Publications by the researcher in collaboration with Antonio García García (38)

2020

  1. Aza-CGP37157-lipoic hybrids designed as novel Nrf2-inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties

    Drug Development Research, Vol. 81, Núm. 3, pp. 283-294

  2. New Nrf2-inducer compound ITH12674 slows the progression of retinitis pigmentosa in the mouse model rd10

    Cellular Physiology and Biochemistry, Vol. 54, Núm. 1, pp. 142-159

2017

  1. Addition to "ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia"

    ACS chemical neuroscience, Vol. 8, Núm. 1, pp. 210

  2. ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia

    ACS Chemical Neuroscience, Vol. 8, Núm. 1, pp. 67-81

  3. Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices

    Neuropharmacology, Vol. 116, pp. 110-121

2015

  1. Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action

    British Journal of Pharmacology, Vol. 172, Núm. 7, pp. 1807-1821

2013

  1. Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

    Neuropharmacology, Vol. 67, pp. 403-411

  2. Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

    Medicinal Research Reviews, Vol. 33, Núm. 1, pp. 139-189

2012

  1. Benzothiazepine CGP37157 and its isosteric 2′-ethyl analogue provide neuroprotection and block cell calcium entry

    ACS Chemical Neuroscience, Vol. 3, Núm. 7, pp. 519-529

  2. Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation

    Neuropharmacology, Vol. 62, Núm. 2, pp. 1082-1090

2011

  1. Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS

    Neurochemistry International, Vol. 58, Núm. 6, pp. 676-683

  2. Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity

    European Journal of Pharmacology, Vol. 660, Núm. 2-3, pp. 411-419

  3. N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235

  4. Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia

    Bioorganic and Medicinal Chemistry, Vol. 19, Núm. 2, pp. 951-960

2010

  1. Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 16, pp. 5861-5872

  2. Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

    Journal of Medicinal Chemistry, Vol. 53, Núm. 14, pp. 5129-5143

2009

  1. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease

    Journal of Medicinal Chemistry, Vol. 52, Núm. 9, pp. 2724-2732

2008

  1. New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

    Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 16, pp. 7759-7769

  2. Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death

    European Journal of Medicinal Chemistry, Vol. 43, Núm. 3, pp. 668-674

2007

  1. An update on the pharmacology of galantamine

    Expert Opinion on Investigational Drugs, Vol. 16, Núm. 12, pp. 1987-1998