Farmacia
Facultad
GlaxoSmithKline (Spain)
Madrid, EspañaPublicaciones en colaboración con investigadores/as de GlaxoSmithKline (Spain) (55)
2021
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A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides
British Journal of Pharmacology, Vol. 178, Núm. 2, pp. 363-377
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The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957
Scientific Reports, Vol. 11, Núm. 1
2020
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Identification of Selective Inhibitors of Plasmodium N-Myristoyltransferase by High-Throughput Screening
Journal of Medicinal Chemistry, Vol. 63, Núm. 2, pp. 591-600
2018
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A high throughput screen for next-generation leads targeting malaria parasite transmission
Nature Communications, Vol. 9, Núm. 1
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Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria" (Antimicrobial Agents and Chemotherapy (2018) 62:9 (e00012-18) DOI: 10.1128/AAC.00012-18)
Antimicrobial Agents and Chemotherapy
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Gametocytes from K13 propeller mutant plasmodium falciparum clinical isolates demonstrate reduced susceptibility to dihydroartemisinin in the male gamete exflagellation inhibition assay
Antimicrobial Agents and Chemotherapy, Vol. 62, Núm. 12
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Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Science, Vol. 359, Núm. 6372, pp. 191-199
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Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials
Journal of Antimicrobial Chemotherapy, Vol. 73, Núm. 5, pp. 1279-1290
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Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones
Journal of Medicinal Chemistry, Vol. 61, Núm. 8, pp. 3422-3435
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Uct943, a next-generation plasmodium falciparum pi4k inhibitor preclinical candidate for the treatment of malaria
Antimicrobial Agents and Chemotherapy, Vol. 62, Núm. 9
2017
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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
Nature Communications, Vol. 8
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Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
Nature Communications, Vol. 8
2016
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A broad analysis of resistance development in the malaria parasite
Nature Communications, Vol. 7
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A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents
Malaria Journal, Vol. 15, Núm. 1
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Transmission-blocking potential of MEFAS, a hybrid compound derived from artesunate and mefloquine
Antimicrobial Agents and Chemotherapy, Vol. 60, Núm. 5, pp. 3145-3147
2015
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A new Set of chemical starting points with Plasmodium falciparum transmission-blocking potential for antimalarial drug discovery
PLoS ONE, Vol. 10, Núm. 8
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Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay
Malaria Journal, Vol. 14, Núm. 1
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Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation
Antimicrobial Agents and Chemotherapy, Vol. 59, Núm. 6, pp. 3298-3305
2013
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Estandarización de un modelo murino de malaria cerebral en fases clínicas para la evaluación de terapias antimaláricas y de rescate
Anales de la Real Academia Nacional de Farmacia, Vol. 79, Núm. 2, pp. 274-292
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Glutathione peroxidase contributes with heme oxygenase-1 to redox balance in mouse brain during the course of cerebral malaria
Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1832, Núm. 12, pp. 2009-2018