Veterinaria
Facultad
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Instituto de Química Orgánica General
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Instituto de Química Orgánica General (45)
2022
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Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout
Journal of Medicinal Chemistry, Vol. 65, Núm. 8, pp. 6250-6260
2020
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Highlights of ASS234: A novel and promising therapeutic agent for Alzheimer's disease therapy
Neural Regeneration Research, Vol. 15, Núm. 1, pp. 30-35
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In Vitro and in Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
ACS Chemical Neuroscience, Vol. 11, Núm. 22, pp. 3793-3801
2019
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Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy
Molecules, Vol. 24, Núm. 8
2018
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Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine
Future Medicinal Chemistry, Vol. 10, Núm. 11, pp. 1289-1300
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In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234
CNS Neuroscience and Therapeutics
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Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy
Chemical Research in Toxicology, Vol. 31, Núm. 9, pp. 839-842
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Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer's Disease Therapy
ACS Chemical Neuroscience, Vol. 9, Núm. 12, pp. 2880-2885
2017
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5-Methyl-: N -(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: A highly potent human cholinesterase inhibitor
MedChemComm, Vol. 8, Núm. 6, pp. 1307-1317
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Corrigendum: Melatonin and nitrones as potential therapeutic agents for stroke [Front. Aging Neurosci., 8 (2016) (281)] DOI:10.3389/fnagi.2016.00281
Frontiers in Aging Neuroscience
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Ischemic brain injury: New insights on the protective role of melatonin
Free Radical Biology and Medicine, Vol. 104, pp. 32-53
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Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration
Future Medicinal Chemistry, Vol. 9, Núm. 8, pp. 765-780
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Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress
Design of Hybrid Molecules for Drug Development (Elsevier Inc.), pp. 5-46
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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
Angewandte Chemie - International Edition, Vol. 56, Núm. 41, pp. 12765-12769
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Recent developments on multi-target-directed tacrines for alzheimer’s disease. I. The pyranotacrines
Current Topics in Medicinal Chemistry, Vol. 17, Núm. 31, pp. 3328-3335
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The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease
Journal of Psychiatry and Neuroscience, Vol. 42, Núm. 1, pp. 59-69
2016
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ASS234, as a new multi-target directed propargylamine for Alzheimer's disease therapy
Frontiers in Neuroscience, Vol. 10, Núm. JUN
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Melatonin and nitrones as potential therapeutic agents for stroke
Frontiers in Aging Neuroscience, Vol. 8, Núm. NOV
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Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices
NeuroToxicology, Vol. 57, pp. 61-68
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Synthesis and biological evaluation of heterocyclic privileged medicinal structures containing (benz)imidazole unit
Monatshefte fur Chemie, Vol. 147, Núm. 12, pp. 2209-2220