Infecciones en trasplante de páncreas-riñónepidemiología, factores de riesgo e impacto en la función del injerto pancreático a largo plazo

Résumé

Combined pancreas and kidney transplantation (PKT) is now considered to be an accepted therapeutic option for patients with diabetes and end-stage renal failure. The increasing success of pancreas transplantation is the result of better surgical techniques, immunosuppressive therapies, and the rational use of antimicrobials. However, and despite such advances, infection remains a major cause of morbidity and mortality after PKT, increasing costs and having a negative impact on graft and patient survival. In contrast to what occurs with other types of transplants, information regarding infectious complications following pancreas transplantation is scant and controversial. Most published studies have focused on specific types of infections or short-term infectious complications, but comprehensive reports involving enough recipients with an adequate follow up are scarce. As a consequence, there is not an infection-related standard of care following pancreas transplantation, and important questions remain to be answered regarding the impact of infection on this type of transplant...