Virus de la hepatitis Cvariabiliad en las regiones del CORE y NS5A y su impacto en la infección por el genotipo 1b

  1. PALOMO LASTRA, MARIA
Supervised by:
  1. Avelina Suárez Moya Director
  2. Juan José Picazo de la Garza Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 22 September 2015

Committee:
  1. José Prieto Prieto Chair
  2. María Luisa Gómez-Lus Centelles Secretary
  3. Ricardo Fernández Roblas Committee member
  4. José Sanz Moreno Committee member
  5. Juan Luis Muñoz Bellido Committee member
Department:
  1. Medicina

Type: Thesis

Teseo: 145360 DIALNET lock_openDocta Complutense editor

Abstract

Hepatitis C virus (HCV) infects an estimated 170 million people worldwide and is regarded to be one of the main causes of chronic hepatitis, terminal liver disease and hepatocellular carcinoma. Until the new antiviral agents were introduced, the genotype 1b was the most prevalent in our patients and had the lowest sustained viral response (SVR) rates, which led to the search for predictive markers of response to be able to identify patients who might benefit from this treatment. Previous studies have shown that mutations either in the coding region of the C protein of the Core region or in the region between the amino acids 2209 and 2248 (interferon sensitivity-­‐determining region: ISDR) of non-­‐structural 5A (NS5A) gene of HCV, are related predictive factors of response to the therapy. The aim of this study was to investigate the mutations in both regions and their impact in patients with chronic HCV 1b infection. It furthermore intends, to analyze other factors involved in the response such us gender, age and baseline viral load...