Tolerancia del alcohol en ratas sometidas a diferentes períodos de consumo agudo y crónico de etanol

  1. Luque, Javier
  2. García Moreno, Luis Miguel
  3. Capilla, Almudena
  4. García Sánchez, Olga
  5. Senderek, Kamila
  6. Arias Pérez, Jorge Luis 1
  7. Conejo Jiménez, Nélida María 1
  1. 1 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

Revista:
Psicothema

ISSN: 0214-9915

Año de publicación: 2004

Volumen: 16

Número: 2

Páginas: 211-216

Tipo: Artículo

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Otras publicaciones en: Psicothema

Resumen

Tolerancia al alcohol en ratas sometidas a diferentes períodos de consumo agudo y crónico de etanol. El desarrollo de tolerancia a los efectos del alcohol no es uniforme, y suele variar según el patrón de consumo previo y actual. En este trabajo se evaluó la temperatura corporal y el tiempo de recuperación de dos reflejos tras el consumo crónico y agudo de elevadas dosis de etanol. Previamente, los animales bebieron alcohol de forma crónica o aguda desde los 21 hasta los 56 y 84 días de edad. Durante los días de evaluación, los animales recibieron una única dosis de etanol al 25% (5 g/kg, i.p.), o la misma cantidad de solución salina. Los resultados mostraron una mayor afectación a los 56 días de consumo crónico elevado de etanol respecto a los 84 días. Con un consumo moderado o agudo de etanol, los animales de 56 días desarrollaron una mayor tolerancia. Sin embargo, esta tolerancia no se observó en cuanto a los déficits motores, dado que todos los grupos necesitaron un largo período de tiempo para recuperar los reflejos

Referencias bibliográficas

  • Acheson, A.K., Richardson, R. and Swartzwelder, H.A. (1999). Developmental changes in seizure susceptibility during ethanol withdrawal. Alcohol, 18: 23-26.
  • American Psychiatryc Association, (1994). Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition (DSM-IV). American Psychiatryc Association. Washington, DC.
  • Capretta, P.J., Petersik, J.T. and Stwart, D.J. (1975). Acceptance of novel flavors is increased after early experience of diverse tastes. Nature, 254, 689-691.
  • Chandler, L.J., Harris, R.A. and Crews, F.T. (1998). Ethanol tolerance and synaptic plasticity. Trends in Pharmacological Sciences, 19, 491-495.
  • Cheema, Z.F., West, J.R. and Miranda, R.C. (2000). Ethanol induces Fas/Apo [apoptosis]-1 nRNA and cell suicide in the developing cerebral cortex. Alcoholism Clinical and Experimental Research, 24, 535-543.
  • Crabbe, J.C., Feller, D.J., Terda, E.S. and Merrill, C.D. (1990). Genetic components of ethanol responses. Alcohol, 7, 245-249.
  • Crabbe, J.C., Janovsky, J.S., Young, E.R., Kosobud, A., Stack, J. and Rigter, H. (1982). Tolerance to ethanol hypothermia in imbred mice: genotypic correlations with behavioral responses. Alcoholism Clinical and Experimental Research, 6, 446-458.
  • Crews, F.T., Steck, J.C., Chandler, L.J., Yu, C.J. and Day, A. (1998). Ethanol, stroke, brain damage, and excitotoxicity. Pharmacology Biochemistry and Behavior, 59, 981-991.
  • Crowell, C.R., Hinson, R.E. and Siegel, S. (1981). The role of conditional drug response in tolerance to the hypothermic effects of ethanol. Psychopharmacology, 73, 51- 54.
  • De Bellis, M.D., Clark, D.B., Beers, S.R., Soloff, P.H., Boring, A.M., Hall, J., Kersh, A. and Keshavan, M.S. (2000). Hippocampal volume in adolescent-onset alcohol use disorders. The American Journal of Psychiatry, 157, 737-744.
  • Devaud, L.L. (2001). Ethanol dependence has limited effects on GABA or glutamate transporters in rat brain. Alcoholism Clinical and Experimental Research, 25, 606-611.
  • Duncan, P.M., Alici, T. and Woodward, J.D. (2000). Conditioned compensatory response to ethanol as indicated by locomotor activity in rats. Behavioural Pharmacology, 11, 395-402.
  • García-Moreno, L.M., Corcuera, M.T., Conejo, N.M., Martín, F.R., Gómez, M. and Alonso, M.J. (1998). Alteraciones hepáticas en un modelo de alcoholismo en ratas. Anual de Medicina Interna, 15, 241- 245.
  • Germani, E., Suck, M.L.T., Di Giulio, A.M. and Gorio, A. (1999). Perinatal supplementation of low doses of ethanol enhances 5-HT restoration in the central nervous system. Journal of Neuroscience Research, 58, 449-455.
  • Gómez Fraguela, J.A., Luengo Martín, A. and Romero Triñanes, E. (2002). Prevención del consumo de drogas en la escuela: cuatro años de seguimiento de un programa. Psicothema, 14(4), 685-692.
  • Grant, K.A. and Lovinger, D.M. (1995). Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clinical Neuroscience, 3, 155-164.
  • Grobin, A.C., Matthews, D.B., Devaud, L.L. and Morrow, A.L. (1998). The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology, 139, 2-19.
  • Hindmarch, I., Kerr, J.S. and Sherwood, N. (1991). The effects of alcohol and other drugs on psychomotor performance and cognitive function. Alcohol Alcohol, 26, 71.
  • Khanna, J.M., Chau, A. and Shah, G. (1996). Characterization of the phenomenon of rapid tolerance to ethanol. Alcohol, 13, 621-628.
  • Khanna, J.M., Kalant, H., Weiner, J. and Shah, G. (1992). Rapid tolerance and cross-tolerance as predictors of chronic tolerance and crosstolerance. Pharmacology Biochemistry and Behavior, 41, 355-360.
  • Khanna, J.M., Shah, G. and Chau, A. (1997). Effect of NMDA antagonists on rapid tolerance to ethanol under two different testing paradigms. Pharmacology Biochemistry and Behavior, 57, 693-697.
  • Lamminpa, A. (1995). Alcohol intoxication in childhood and adolescence. Alcohol Alcohol, 30, 5-12.
  • Le, A.D., Khanna, J.M. and Kalant, H. (1984). Effect of treatment dose and test system on the development of ethanol tolerance and physical dependence. Alcohol, 1: 447-451.
  • Lomax, P., Bajorek, J.G., Chesarek, W.A. and Chafee, R.R. (1980). Ethanol-induced hypothermia in the rat. Pharmacology, 21, 288-294.
  • Markwiese, B.J., Acheson, S.K., Levin, E.D., Wilson, W.A. and Swartzwelder, H.S. (1998). Differential effects of ethanol on memory in adolescent and adult rats. Alcoholism Clinical and Experimental Research, 22, 416-421.
  • Maylor, E.A. and Rabbitt, P.M.A. (1993). Alcohol, reaction time and memory: a meta-analisys. British Journal of Psychology, 84, 301-317.
  • Meldrum, B. and Gartwaite, J. (1990). Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends in Pharmacological Sciences, 11, 379-387.
  • Nagy, J., Muller, F. and Laszlo, L. (2001). Cytotoxic effect of ethanolwithdrawal on primary cultures of cortical neurons. Drug and Alcohol Dependence, 61, 155-162.
  • Naranjo, C.A. and Bremner, K.E. (1993). Behavioural correlates of alcohol intoxication. Addiction, 88, 25-35.
  • Neznanova, O.N., Blokhina, E.A., Sukhotina, I.A. and Bespalov, A.Y. (2000). Motor impairment produced by ethanol and site-selective NMDA receptor antagonists in micetolerance and cross-tolerance. Alcohol, 20, 31-36.
  • Olney, J.W. (1990). Excitotoxin-mediated neuron death in youth and old age. Progress in Brain Research, 86, 37-51.
  • Orrenius, S., McConkey, D.J., Bellomo, G. and Nicotera, P. (1989). Role of Ca2+ in toxic cell killing. Trends in Pharmacological Sciences, 10, 281-285.
  • Pellis, S.M. and Pellis, V.C. (1994). Development of righting when falling from a bipedal standing posture: evidence for the dissociation of dynamic and static righiting reflexes in rats. Physiology and Behavior, 56, 659-663.
  • Pellis, S.M., Pellis, V.C. and Nelson, J.E. (1992). The development of righting reflexes in the pouch young of the marsupial Dasyurus Hallucatus. Developmental Psychobiology, 25, 105-125.
  • Pellis, S.M., Pellis, V.C. and Whishaw, I.Q. (1996). Visual modulation of air righting by rats involves calculation of time-to-impact, but does not require the detection of the looming stimulus of the approaching ground. Behavioural Brain Research, 74, 207-211.
  • Peris, J, and Cunningham, C.L. (1987). Stress enhances the development of tolerance to the hypothermic effect of ethanol. Alcohol and Drug Research, 7, 187-193.
  • Pohorecky, L.A., Brick, J. and Carpenter, J.A. (1986). Assessment of the development of tolerance to ethanol using multiple measures. Alcoholism Clinical and Experimental Research, 10, 616-622.
  • Pyapali, G.K., Turner, D.A., Wilson, W.A. and Swartzwelder, H.S. (1999). Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation. Alcohol, 19, 107-111.
  • Rodríguez Franco, L., Padilla Muñoz, E., Caballero, R. and Rodríguez, J. (2002). Ansiedad en hijos de padres alcohólicos en tratamiento. Psicothema, 14(1), 9-18.
  • Silva, S.M., Paula-Barbosa, M.M. and Madeira, M.D. (2002). Prolonged alcohol intake leads to reversible depression of corticotropin-releasing hormone and vasopressin immunoreactivity and mRNA levels in the parvocellular neurons of the paraventricular nucleus. Brain Research, 954, 82-93.
  • Smothers, C.T., Mrotek, J.J. and Lovinger, D.M. (1997). Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons. Journal of Pharmacology and Experimental Therapeutics, 283, 1214-1222.
  • Steffensen, S.C., Nie, Z., Criado, J.R. and Siggins, G.R. (2000). Ethanol inhibition of N-metyl-D-aspartate receptors involves presynaptic gamynobutiric acid (B) receptors. Journal of Pharmacology and Experimental Therapeutics, 294, 637-697.
  • Swartzwelder, H.S., Richardson, R.C., Markwiese-Foerch, B., Wilson, W.A and Little, P.J. (1998). Developmental differences in the acquisition of tolerance to ethanol. Alcohol, 4, 311-314.
  • Swartzwelder, H.S., Wilson, W.A. and Tayyeb, M.Y. (1995). Agedependent inhibition of long-term potentiation by ethanol in inmature vs mature hippocampus. Alcoholism Clinical and Experimental Research, 19, 1480-1485.
  • Tang, M. and Falk, J.L. (1986). Chronic alcohol dependence and waterelectrolyte status. Alcohol, 3, 33-37.
  • Tracy, H.A. and Wayner, M.J. (1998). Losartan blocks diazepam and ethanol effects on air righting. Alcohol, 16, 93-99.
  • Tracy, H.A., Wayner, M.J. and Armstrong, D.L. (1999). Nicotine blocks ethanol and diazepam impairment of air righting and ethanol impairment of maze performance. Alcohol, 18, 123-130.
  • Vazquez, D.M. (1998). Stress and the developing limbic-hypothalamicpituitary-adrenal axis. Psychoneuroendocrinology, 23, 663-700.
Fuente de los datos: Dialnet