Papel de las estatinas en la enfermedad renal crónica (ERC)
- Goicoechea Diezhandino, Maria Angeles
- García de Vinuesa, Soledad
- Lahera Juliá, Vicente
- Cachofeiro Ramos, María Victoria
- Verdalles Guzmán, Úrsula
- Luño Fernández, José
ISSN: 0214-9168, 1578-1879
Ano de publicación: 2010
Volume: 22
Número: 1
Páxinas: 17-24
Tipo: Artigo
Outras publicacións en: Clínica e investigación en arteriosclerosis
Resumo
Statins have been shown to reduce cardiovascular morbidity and mortality in the general population. In addition to their cholesterol-lowering effect, these drugs have other protective pleiotropic effects on the cardiovascular system. However, the effect of statins on cardiovascular risk in patients with chronic renal disease (CRD) is controversial. Moreover, the question of whether statins delay the progression of CRD and the effect of these drugs on proteinuria remain to be elucidated. The present review discusses the lipid alterations present in CRD and the possible effects of statins on inflammation, CRD progression, proteinuria and cardiovascular risk in this population group.