Hipertensión portaldesarrollo de una respuesta inflamatoria sistémica asociada a síndrome metabólico

  1. Heras Jiménez, Natalia de las
  2. Aller Reyero, María Angeles
  3. Revuelta López, Elena
  4. Baeza, Gema
  5. Cachofeiro Ramos, María Victoria
  6. Arias Pérez, Jaime
  7. Lahera Juliá, Vicente
Journal:
Clínica e investigación en arteriosclerosis

ISSN: 0214-9168 1578-1879

Year of publication: 2012

Volume: 24

Issue: 3

Pages: 157-166

Type: Article

More publications in: Clínica e investigación en arteriosclerosis

Metrics

SCImago Journal Rank

  • Year 2012
  • SJR Journal Impact: 0.133
  • Best Quartile: Q4
  • Area: Cardiology and Cardiovascular Medicine Quartile: Q4 Rank in area: 262/357
  • Area: Pharmacology (medical) Quartile: Q4 Rank in area: 197/274

Scopus CiteScore

  • Year 2012
  • CiteScore of the Journal : 0.2
  • Area: Pharmacology (medical) Percentile: 18
  • Area: Cardiology and Cardiovascular Medicine Percentile: 17

Abstract

Portal hypertension (PH) is characterised by increase in portal venous pressure by obstruction of portal flow. As a consequence of PH, a collateral circulation is developed, which shifts an important part of portal flow to the systemic circulation. Furthermore, hepatic steatosis is another feature of PH in the rat, which is also, associated which different risk factors such as, obesity, diabetes, hypercholesterolemia and hypertrygliceridemia. Several mechanisms such as insulin resistance, cytokine production and oxidative stress participate in the development of this clinical pathology. An experimental model of pre-hepatic portal hypertension by triple partial portal vein ligation enables complications produced both short-term or acute and long-term or chronic outcome to be studied. Most of the splanchnic and systemic alterations produced in this experimental model are of an inflammatory nature, and for this reason the study of the physiological mechanisms involved are of great interest to the research of new anti-inflammatory therapies.