Reducción de la permeabilidad corneal en pacientes tratados con HP-Guarestudio fluorofotométrico

  1. I. Cerván-López
  2. F. Sáenz-Francés-San-Baldomero
  3. J.M. Benítez-Del-Castillo
  4. J. García-Sánchez
Revista:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Año de publicación: 2006

Volumen: 81

Número: 6

Páginas: 327-332

Tipo: Artículo

DOI: 10.4321/S0365-66912006000600006 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Archivos de la Sociedad Española de Oftalmologia

Resumen

Introducción: El ojo seco es una enfermedad en la que entre otras estructuras se afecta el epitelio corneal. El tratamiento de primera línea siguen siendo los sustitutivos lagrimales que buscan lograr una buena humidificación y lubricación del epitelio corneal de estos pacientes, evitando así su progresivo deterioro funcional. El HP-Guar es un compuesto novedoso cuyos resultados sintomáticos en los pacientes con ojo seco están siendo prometedores. Métodos: Presentamos un estudio prospectivo, enmascarado, pareado sobre 10 ojos izquierdos de 10 pacientes con ojo seco, a los que se les realizó medidas de la permeabilidad corneal mediante fluorofotometría con la instilación de 40 microlitros de una solución de fluoresceína sódica al 2%, antes y después del tratamiento con HP-Guar. Se analizaron los resultados con el test de Wilcoxon para datos pareados. Resultados: Se observó tuvo una disminución estadísticamente significativa de la permeabilidad corneal media del 45% tras tratamiento con HP-Guar (p= 0,002). Conclusiones: El HP-Guar constituye una nueva opción terapéutica que ha demostrado fluotofotométricamente reducir la permeabilidad epitelial corneal tras su uso.

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