Papel de la isoforma A del receptor de la insulina y del IGF-1R en el crecimiento de la placa aterosclerótica

  1. Almudena Gómez Hernández
  2. Nuria Beneit Redondo
  3. Liliana Perdomo Loaiza
  4. Oscar Escribano Illanes
  5. Sabela Diaz Castroverde Vicario
  6. Manuel Benito de las Heras
Anales de la Real Academia Nacional de Farmacia

ISSN: 1697-4298 0034-0618

Year of publication: 2016

Volume: 82

Issue: 2

Pages: 129-142

Type: Article

More publications in: Anales de la Real Academia Nacional de Farmacia


In this work, we have obtained new lines of vascular smooth muscle cells (VSMCs) to demonstrate that IRA and IRA/IGF-1R might confer a proliferative and migratory advantage in response to insulin, IGF-2 or TNF-α. These results might be relevant due to in the early stages of atherosclerotic process; we have demonstrated that there is a significant increase of IRA and IGF-1R expression as well as higher formation of hybrid receptors in the aorta from two models of early atherosclerosis. Finally, anti-TNF-α treatment prevented vascular alterations