Antitumorigenic mechanisms of action of peroxisome proliferator-activated gamma (ppargamma) ligands in breast cancer

  1. DORADO PEREZ, JORGE
Dirigida por:
  1. Ana María Pérez Castillo Director/a

Universidad de defensa: Universidad Autónoma de Madrid

Fecha de defensa: 20 de noviembre de 2009

Tribunal:
  1. Pilar Santisteban Presidente/a
  2. I. Ibáñez de Cáceres Secretario/a
  3. Jorge Martín Pérez Vocal
  4. Gregorio Angel Santos Montes Vocal
  5. Rosario Perona Abellón Vocal

Tipo: Tesis

Teseo: 283675 DIALNET lock_openBiblos-e Archivo editor

Resumen

In this work we have analyzed the antitumorigenic mechanisms of action of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) ligands 15-deoxi-12,14-Prostaglandin J2 , rosiglitazone and pioglitazone on human breast cancer cells. Our data show that treatment with these compounds reduces cell viability, induces inhibition of proliferation and promotes apoptosis in several breast carcinoma cell lines, and attribute for the first time similar effects to members of the thiadiazolidinones (TDZDs) family of compounds.