Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development
- APELLANIZ UNZALU, BEATRIZ
- Jose Luis Nieva Escandón Director/a
Universidad de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea
Fecha de defensa: 11 de junio de 2012
- Jesús Pérez Gil Presidente
- Francesc Xabier Contreras Gómez Secretario/a
- Enrique Pérez Payá Vocal
- Jamie K. Scott Vocal
- Gorka Basañez Asua Vocal
Tipo: Tesis
Resumen
1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.