Genetic regulation of aflatoxin, ochratoxin A, trichothecene, and fumonisin biosynthesisA review
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Universidad Complutense de Madrid
info
ISSN: 1618-1905
Datum der Publikation: 2020
Ausgabe: 23
Nummer: 1
Seiten: 89-96
Art: Artikel
Andere Publikationen in: International microbiology: official journal of the Spanish Society for Microbiology
Zusammenfassung
Mycotoxins are a significant food safety concern. Aflatoxins, trichothecenes, fumonisins, and ochratoxin A are considered the most important mycotoxins due to their frequent occurrence in food products and their well-known toxicity. The regulation of mycotoxin biosynthesis occurs mainly at transcriptional level, and specific regulators have been described in every biosynthetic cluster. Secondary metabolite production, including mycotoxin synthesis, is also regulated by general regulator pathways affected by light, osmotic stress and oxidative stress, among others. This review is focused on this genetic regulation of mycotoxin biosynthesis by specific genes and global regulators.