Valor predictivo negativo del SPECT con Ioflupano 123I en los trastornos del movimiento

  1. Justo Serrano Vicente
  2. Lucía García Bernardo
  3. Carmen Durán Barquero
  4. A.B. Constantino
  5. José Rafael Infante de la Torre
  6. M. Luz Domínguez
  7. Juan Ignacio Rayo Madrid
  8. Román Sánchez Sánchez
  9. Carmen Durán Herrera
Revista española de medicina nuclear

ISSN: 0212-6982

Year of publication: 2009

Volume: 28

Issue: 1

Pages: 2-5

Type: Article

DOI: 10.1016/S0212-6982(09)70207-1 DIALNET GOOGLE SCHOLAR

More publications in: Revista española de medicina nuclear

Sustainable development goals


Objective: A non-degenerative etiology is supported by a normal SPI [normal SPECT with 123I-Ioflupane (SPI)] in a patient with movement disorders (MD). Method: A total of 196 SPIs were conducted during the period of 2004/05. Of these, 44 were selected in order to rule out degenerative MD (DMD), the results being normal in these patients. The clinical background of these patients were reviewed in a minimum period of 24 months (range 24-40), collecting the diagnoses reached by the neurology specialists. The SPI were evaluated using a consensus, according to subjective criteria and quantification. Results: Thirty-six of the 44 patients (81%) were identified at 2 years of having nondegenerative movement disorders: 18 as essential tremor, 5 as drug-induced disorder, 4 as vascular disease, 3 as peripheral polyneuropathy, 2 postural tremors, 1 writer's cramp, 1 psychogenic tremor, 1 intercranial hypertension and 1 fibromyalgia. The remaining 8 patients were diagnosed with Parkinson's disease in 5 cases, 1 corticobasal degeneration, 1 multisystemic atrophy and another degenerative Parkinsonism with unclear etiology. Conclusion: The SPI in our hospital has a lower negative predictive value than the data reported in the literature. The false negatives could be explained because most of our patients come from neurologist physicians who are not movement disorder experts. In addition, a small proportion of degenerative Parkinsonism could evolve with normal SPI.