Evolución cognitiva y calidad de vida tras la erradicación del virus de la hepatitis C - estudio ECOVIC

  1. Ibañez Samaniego, Luis
Supervised by:
  1. Rita Garcia Martinez Director
  2. Rafael Bañares Cañizares Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 15 February 2021

Committee:
  1. Luis Antonio Álvarez-Sala Walther Chair
  2. I. Fernández Vázquez Secretary
  3. María Buti Ferret Committee member
  4. José Luis Calleja Panero Committee member
  5. Agustín Albillos Martínez Committee member
Department:
  1. Medicina

Type: Thesis

Teseo: 155079 DIALNET lock_openDocta Complutense editor

Abstract

Chronic hepatitis C virus (HCV) infection influences cognitive function in some patients which is associated with a decrease in health-related quality of life (HRQoL) and functioning. According to the stage of liver disease, two different pathophysiological mechanisms are involved in cognitive impairment (CI). Before the development of cirrhosis, a direct neuropathic effect of the HCV prevails, while in the cirrhotic stage liver failure is the main driver of cognitive dysfunction. The way that both mechanisms interplay in patients with advanced liver disease is unknown, as well as the effect that viral eradication with the new direct antiviral agents (DAA) may have on cognitive function and HRQoL. ENDPOINTS: 1. To describe cognitive function, mood, functioning and HRQoL according to the stage of liver disease at baseline and after viral eradication. 2. To identify characteristics related to the presence of CI at baseline and after HCV eradication...