Marcadores de envejecimiento cronológico y patológico

  1. Kobayashi García, Hikaru
Supervised by:
  1. Mónica González Sánchez Director
  2. Mónica de la Fuente del Rey Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 05 July 2021

Committee:
  1. José Manuel Martín Villa Chair
  2. Eva Maria Gonzalez Arana Secretary
  3. Gustavo Ramón Plaza Baonza Committee member
  4. Antonio Garrido Tarrío Committee member
  5. Carmen Guaza Rodriguez Committee member
Department:
  1. Genética, Fisiología y Microbiología

Type: Thesis

Abstract

Ageing is a universal, intrinsic, progressive and deleterious process characterized by the general loss of organismal function and by a reduced ability of adaptation to changes, i.e. a worse homeostasis maintenance, which is accompanied by increased morbidity and mortality. Ageing is characterized by a high individual heterogeneity, by which members of the same group, with the same chronological age, don’t necessarily display the same rate of ageing, also termed “biological age”, which proves to be a better estimator of how the individual is ageing and of its life expectancy, than the chronological age.The theory of oxidation-inflammation postulates that ageing would be the result of chronic oxidative and inflammatory stress that would affect all cells in the body, but that its consequences would be greater in homeostatic systems (nervous, endocrine and immune). In addition, the immune system, due to its characteristic releasing of oxidative and inflammatory compounds to perform its function, could modulate the oxidative-inflammatory stress of the body and consequently the rate at which ageing occurs...