Estrategias de guía e ingredientes dietéticos de precisión para enfermedades crónicas en población pre-sénior y sénior

  1. Galarregui, C.
  2. Abete, I.
  3. Navas, S.
  4. Reglero, G.
  5. Ramírez de Molina, A.
  6. Loria, V.
  7. Zulet, M.Á.
  8. Martínez, J.A.
Revista:
Anales del sistema sanitario de Navarra

ISSN: 1137-6627

Año de publicación: 2018

Volumen: 41

Número: 2

Páginas: 227-242

Tipo: Artículo

DOI: 10.23938/ASSN.0311 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Anales del sistema sanitario de Navarra

Resumen

El envejecimiento de la población supone un importante reto, económico y cualitativo, para el sistema de salud orientándolo hacia una atención de tipo preventivo, en la que la nutrición de precisión (NP) y la prescripción de hábitos saludables adquieren relevancia capital.El fin de la NP es procurar una nutrición adaptada a cada individuo, entendiendo que la prevención o el tratamiento de trastornos crónicos (obesidad, diabetes, enfermedad cardiovascular, etc.) deben abordarse de un modo integral, considerando información personal y clínica relevante, edad y características feno- y genotípicas.La elaboración de la presente guía surge de la necesidad de desarrollar modelos nutricionales de precisión que permitan la individualización del tratamiento nutricional, con énfasis en el adulto mayor. Las necesidades nutricionales, las recomendaciones dietéticas y los ingredientes para una NP en las personas pre-sénior y sénior quedan resumidas en realizar al menos 3 comidas diarias, reducir las calorías totales, optar por una alimentación variada y equilibrada con alimentos frescos y de alta densidad nutricional, incorporar verduras, legumbres y pescado, consumir productos lácteos y fibra, preferir carnes blancas en lugar de rojas, evitar frituras, embutidos y alimentos procesados, moderar el consumo de sal, café y alcohol, e hidratarse adecuadamente. 

Referencias bibliográficas

  • NG M, FLEMING T, ROBINSON M, THOMSON B, GRAETZ N, MARGONO C et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766-781.
  • VAISERMAN A, LUSHCHAK O. Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives. J Transl Med 2017; 15: 160.
  • MARTIN MA, GOYA L, RAMOS S. Protective effects of tea, red wine and cocoa in diabetes. Evidences from human studies. Food Chem Toxicol 2017; 109: 302-314.
  • DE LA GARZA AL, ETXEBERRIA U, HASLBERGER A, AUMUELLER E, MARTÍNEZ JA, MILAGRO FI. Helichrysum and grapefruit extracts boost weight loss in overweight rats reducing inflammation. J Med Food 2015; 18: 890-898.
  • SAN-CRISTOBAL R, MILAGRO FI, MARTINEZ JA. Future challenges and present ethical considerations in the use of personalized nutrition based on genetic advice. J Acad Nutr Diet 2013; 113: 1447-1454.
  • GONI L, CUERVO M, MILAGRO FI, MARTÍNEZ JA. Future perspectives of personalized weight loss interventions based on nutrigenetic, epigenetic, and metagenomic data. J Nutr 2016; 146: 905-912.
  • RAMOS-LOPEZ O, MILAGRO FI, ALLAYEE H, CHMURZYNSKA A, CHOI MS, CURI R, et al. Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic: approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J Nutrigenet Nutrigenomics 2017; 10: 43-62.
  • MARTÍNEZ J, MILAGRO FI. Genetics of weight loss: a basis for personalized obesity management. Trends Food Sci Technol 2015; 42: 97-115.
  • STEEMBURGO T, AZEVEDO MJ, MARTÍNEZ JA. Gene-nutrient interaction and its association with obesity and diabetes mellitus. Arq Bras Endocrinol Metabol 2009; 53: 497-508.
  • MARTÍNEZ JA, MILAGRO FI, CLAYCOMBE KJ, SCHALINSKE KL. Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr 2014; 5: 71-81.
  • Federación Española de Sociedades de Nutrición, Alimentación y Dietética (FESNAD). Ingestas Dietéticas de Referencia (IDR) para la población española. Pamplona: EUNSA; 2010.
  • DE TORO-MARTÍN J, ARSENAULT BJ, DEPRÉS JP, VOHL MC. Precision nutrition: a review of personalized nutritional approaches for the prevention and management of metabolic Syndrome. Nutrients 2017; 22; 9(8).
  • CROWE KM, FRANCIS C; Academy of Nutrition and Dietetics. Position of the Academy of Nutrition and Dietetics: functional foods. J Acad Nutr Diet 2013; 113: 1096-1103.
  • LIBERATI A, ALTMAN DG, TETZLAFF J, MULROW C, GØTZSCHE PC, IOANNIDIS JP et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009; 62: 1-34.
  • LARSEN TM, DALSKOV SM, VAN BAAK M, JEBB SA, PAPADAKI A, PFEIFFER AF et al; Diet, Obesity, and Genes (Diogenes) Project. Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med 2010; 363: 2102-2113.
  • RAYNOR HA, CHAMPAGNE CM. Position of the Academy of Nutrition and Dietetics: interventions for the treatment of overweight and obesity in adults. J Acad Nutr Diet 2016; 116: 129-147.
  • GARGALLO M, BASULTO J, BRETON I, QUILES J. Recomendaciones nutricionales basadas en la evidencia para la prevención del sobrepeso y la obesidad en adultos (Consenso FESNAD SEEDO). Revista Española de Obesidad 2011; 9: 5-77.
  • MILLION M, LAGIER JC, YAHAV D, PAUL M. Gut bacterial microbiota and obesity. Clin Microbiol Infect 2013; 19: 305-313.
  • American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2010; 33: 11-53.
  • Fundación redGDPS. http://www.redgdps.org/. Consultado el 15 de abril de 2018.
  • HERNÁNDEZ RUIZ DE EGUILAZ M, BATLLE MA, MARTÍNEZ DE MORENTIN B, SAN-CRISTÓBAL R, PÉREZ-DÍEZ S, NAVAS-CARRETERO S et al. Alimentary and lifestyle changes as a strategy in the prevention of metabolic syndrome and diabetes mellitus type 2: milestones and perspectives. An Sist Sanit Navar 2016; 39: 269-289.
  • CARRILLO L, DALMAU J, MARTINEZ JR, SOLA R, PÉREZ F. Grasa de la dieta y salud cardiovascular. Documento de consenso avalado por la Sociedad Española de Dietética y Ciencias de la Alimentación (SEDCA), la Sociedad Española de Arteriosclerosis (SEA), la Asociación Española de Pediatría/Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (AEP/SEGHNP) y la Sociedad Española de Medicina Familiar y Comunitaria (semFYC). Clin Invest Arterioscl 2011; 23: 1-36.
  • SIEBENHOFER A, JEITLER K, HORVATH K, BERGHOLD A, POSCH N, MESCHIK J et al. Long-term effects of weight-reducing drugs in people with hypertension. Cochrane Database Syst Rev 2016; 3: CD007654.
  • GRANT PJ, CHAIRPERSON E, GERMANY SDA, FRANCE ND, UK CD, GERMANY HH et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD the European Society of Cardiology (ESC) and developed in collaboration. 2013; 34: 3035-3087.
  • MANCIA G, DE BACKER G, DOMINICZAK A, CIFKOVA R, FAGARD R, GERMANO et al. Guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105-1187.
  • CHANSON-ROLLE A, AUBIN F, BRAESCO V, HAMASAKI T, KITAKAZE M. Influence of the lactotripeptides isoleucine-proline-proline and valine-proline-proline on systolic blood pressure in japanese subjects: a systematic review and meta-analysis of randomized controlled trials. PLoS One 2015; 4: 10. doi: 10.1371/journal.pone.0142235.
  • Uenishi K. Evidence of dietary therapy for osteoporosis. Clin Calcium 2008; 18: 1397-1403.
  • LANHAM-NEW SA. Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment. Proc Nutr Soc 2008; 67: 163-176.
  • ORIA E. Factores preventivos y nutricionales de la osteoporosis. An Sist Sanit Navar 2003; 26: 81-90.
  • LORENTE-CEBRIÁN S, COSTA AG, NAVAS-CARRETERO S, ZABALA M, LAIGLESIA LM, MARTÍNEZ JA et al. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. J Physiol Biochem 2015; 71: 341-349.
  • WEI P, LIU M, CHEN Y, CHEN DC. Systematic review of soy isoflavone supplements on osteoporosis in women. Asian Pac J Trop Med 2012; 5(3): 243-248.
  • Food and Agriculture Organization of the United Nations. World Health Organization. Guidelines for the evaluation of probiotics in food. http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf. Consultado el 10 de noviembre de 2017.
  • SCHREZENMEIR J, DE VRESE M. Probiotics, prebiotics, and synbiotics—approaching a definition. Am J Clin Nutr 2001; 73: 361-364.
  • MANSUETO P, SEIDITA A, D'ALCAMO A, CARROCCIO A. Role of FODMAPs in patients with irritable bowel syndrome. Nutr Clin Pract 2015; 30: 665-682.
  • Manual MSD versión para público general. Dislipidemia (dislipemia) - Trastornos hormonales y metabólicos. 2017. https://www.msdmanuals.com/es-es/hogar/trastornos-hormonales-y-metabólicos/trastornos-relacionados-con-el-colesterol/dislipidemia-dislipemia. Consultado el 20 de noviembre de 2017.
  • Foro Dislipidemia Aterogénica. Documento de Consenso. Consenso multidisciplinar sobre dislipidemia aterogénica. Clin Invest Arterioscl 2013; 25: 83-91.
  • BALK EM, LICHTENSTEIN AH, CHUNG M, KUPELNICK B, CHEW P, LAU J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 2006; 189: 19-30.
  • SIRI-TARINO PW, SUN Q, HU FB, KRAUSS RM. Saturated fat, carbohydrate and cardiovascular disease. Am J Clin Nutr 2010; 91: 502-509.
  • CARMENA R, ORDOVÁS JM. Tratamiento dietético de las hiperlipemias primarias. En Hiperlipemias: clínica y tratamiento. Barcelona: Doyma 1999: 203-215.
  • MARTÍNEZ VALLS JF, GABALDÓN J, CIVERA M. Tratamiento dietético de las dislipemias. En: Real JT, Ampudia FJ, Ascaso J, eds. Endocrinología y Nutrición: protocolos diagnóstico-terapéuticos. Valencia, Ed Servicio de Endocrinologia y nutrición HCUV. 2011: 328-330.
  • CONNOR WE, CONNOR SL. The importance of fish and docosahexaenoic acid in Alzheimer disease. Am J Clin Nutr 2007; 85: 929-930.
  • ALBERCA R. ENFERMEDAD DE ALZHEIMER. EN: MOLINUEVO JL, PEÑA-CASANOVA J, EDS. Guía oficial para la práctica clínica en demencias: conceptos, criterios y recomendaciones. Barcelona: Thomson Reuters (Prous Science, SAU); 2009: 61-85.
  • CALDER PC. n-3 fatty acids, inflammation, and immunity—relevance to postsurgical and critically ill patients. Lipids 2004; 39: 1147-1161.
  • SERHAN CN, BRAIN SD, CHRISTOPHER D, BUCKLEY CD, GILROY DW, HASLETT C et al. Resolution of inflammation: state of the art, definitions and terms. FASEB J 2007; 2: 325-332.
  • BALEZTENA J, ARANA M, CASTELLANOS MC, GOZALO MJ. ¿La ingesta o suplementación con ácidos grasos omega-3 a partir de los 65 años influye en la función cognitiva? Resultados de una revisión sistemática An Sist Sanit Navar 2017; 40: 433-442.
  • GIUGLIANO D, MAIORINO MI, ESPOSITO K. Linking prediabetes and cancer: A complex issue. Diabetologia 2015; 58: 201-202.
  • BRAY GA, SMITH SR, DE JONGE L, XIE H, ROOD J, MARTIN CK et al. Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: A randomized controlled trial. JAMA 2012; 307: 47-55.
  • RIZKALLA SW, BELLISLE F, SLAMA G. Health benefits of low glycaemic index foods, such as pulses, in diabetic patients and healthy individuals. Br J Nutr 2002; 88: 255-262.
  • MADSEN L, MYRMEL LS, FJÆRE E, LIASET B, KRISTIANSEN K. Links between dietary protein sources, the gut microbiota, and obesity. Front Physiol 2017; 19; 8:1047.
  • LOPEZ-LEGARREA P, DE LA IGLESIA R, ABETE I, NAVAS-CARRETERO S, MARTINEZ JA, ZULET MA. The protein type within a hypocaloric diet affects obesity-related inflammation: the RESMENA project. Nutrition 2014; 30: 424-429.
  • ABETE I, GOYENECHEA E, ZULET MA, MARTÍNEZ JA. Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutr Metab Cardiovasc Dis 2011; 21: 1-15.
  • RATNAYAKE WM, GALLI C. Fat and fatty acid terminology, methods of analysis and fat digestion and metabolism: abackground review paper. Ann Nutr Metab 2009; 55: 8-43.
  • MIŠURCOVÁ L, VÁVRA AMBROŽOVÁ J, SAMEK D. Seaweed lipids as nutraceuticals. Adv Food Nutr Res 2011; 64: 339-355.
  • CALDER PC. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta 2015; 1851: 469-484.
  • GALANO J-M, MAS E, BARDEN A, MORI TA, SIGNORINI C, DE FELICE C et al. Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans. Prostaglandins Other Lipid Mediat 2013; 107: 95-102.
  • WEN YT, DAI JH, GAO Q. Effects of Omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: A meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 2014; 24: 470-475.
  • LOPEZ-HUERTAS E. The effect of EPA and DHA on metabolic syndrome patients: A systematic review of randomised controlled trials. Br. J. Nutr 2012; 107: 185-194.
  • PARKS EJ, HELLERSTEIN MK. Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr 2000; 71: 412-433.
  • SIRTORI CR, GALLI C, ANDERSON JW, SIRTORI E, ARNOLDI A. Functional foods for dyslipidaemia and cardiovascular risk prevention. Nutr Res Rev 2009; 22: 244-261.
  • YAO B, FANG H, XU W, YAN Y, XU H, LIU Y et al. Dietary fiber intake and risk of type 2 diabetes: a dose-response analysis of prospective studies. Eur J Epidemiol 2014; 29: 79-88.
  • SUN FH, LI C, ZHANG YJ, WONG SH, WANG L. Effect of glycemic index of breakfast on energy intake at subsequent meal among healthy people: a meta-analysis. Nutrients 2016; 8: 37.
  • BARREA L, BALATO N, DI SOMMA C, MACCHIA PE, NAPOLITANO M, SAVANELLI MC et al. Nutrition and psoriasis: Is there any association between the severity of the disease and adherence to the Mediterranean diet? J. Transl. Med 2015; 13:18. doi: 10.1186/s12967-014-0372-1.
  • BERNAUD FS, RODRIGUES TC. [Dietary fiber-adequate intake and effects on metabolism health]. Arq Bras Endocrinol Metabol 2013; 57: 397-405.
  • ANDERSON JW, BAIRD P, DAVIS RH JR, FERRERI S, KNUDTSON M, KORAYM A et al. Health benefits of dietary fiber. Nutr Rev 2009; 67: 188-205.
  • MEYER D. Health benefits of prebiotic fibers. Adv Food Nutr Res 2015: 74: 47-91.
  • KACZMARCZYK MM, MILLER MJ, FREUND GG. The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism. 2012; 61: 1058-1166.
  • PEREIRA MA, LUDWIG DS. Dietary fiber and body-weight regulation. Observations and mechanisms. Pediatr Clin North Am 2001; 48: 969-980.
  • HOWARTH NC, SALTZMAN E, ROBERTS SB. Dietary fiber and weight regulation. Nutr Rev 2001; 59, 129-139.
  • PARNELL JA, REIMER RA. Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome. Gut Microbes 2012; 3: 29-34.
  • ELLULU MS. Obesity, cardiovascular disease, and role of vitamin C on inflammation: a review of facts and underlying mechanisms. Inflammopharmacology 2017; 25: 313-328.
  • KUCK JL, BASTARACHE JA, SHAVER CM, FESSEL JP, DIKALOV SI, MAY JM et al. Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Biochem Biophys Res Commun 2018; 495: 433-437.
  • MALAFARINA V, URIZ-OTANO F, MALAFARINA C, MARTINEZ JA, ZULET MA. Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial. Maturitas 2017; 101: 42-50.
  • IBERO-BARAIBAR I, NAVAS-CARRETERO S, ABETE I, MARTINEZ JA, ZULET MA. Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: longitudinal study. Clin Nutr 2015; 34: 1010-1017.
  • MALAFARINA V, URIZ-OTANO F, GIL-GUERRERO L, INIESTA R, ZULET MA, MARTINEZ JA. Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. The HIPERPROT-GER study. Maturitas 2013; 76: 123-128.
  • MAJOR GC ALARIE FP, DORE J, TREMBLAY A. Calcium plus vitamin D supplementation and fat mass loss in female very low-calcium consumers: potential link with a calcium-specific appetite control. Br J Nutr 2009; 101: 659-663.
  • ZEMEL MB, DONNELLY JE, SMITH BK, SULLIVAN DK, RICHARDS J, MORGAN-HANUSA D et al. Effects of dairy intake on weight maintenance. Nutr Metab (Lond) 2008; 5: 28. doi: 10.1186/1743-7075-5-28.
  • HOUSTON M. The role of noninvasive cardiovascular testing applied clinical nutrition and nutritional supplements in the prevention and treatment of coronary heart disease. Ther Adv Cardiovasc Dis 2018; 12: 85-108.
  • MAZIDI M, KENGNE AP, MIKHAILIDIS DP, TOTH PP, RAY KK, BANACH M. Dietary food patterns and glucose/insulin homeostasis: a cross-sectional study involving 24,182 adult Americans. Lipids Health Dis 2017; 16:192. doi: 10.1186/s12944-017-0571-x.
  • MYERS VH CHAMPAGNE CM. Nutritional effects on blood pressure. Curr Opin Lipidol 2007; 18: 20-24.
  • TOXQUI L, DE PIERO A, COURTOIS V, BASTIDA S, SÁNCHEZ-MUNIZ FJ, VAQUERO MP. Iron deficiency and overload. Implications in oxidative stress and cardiovascular health. Nutr Hosp 2010; 25: 350-365.
  • DEV S, BABITT JL. Overview of Iron Metabolism in Health and Disease. Hemodial Int 2017; 21: 6-20.
  • SANGANI RG, GHIO AJ. Iron, Human growth, and the global epidemic of obesity. Nutrients 2013; 5: 4231-4249.
  • BROUWER-BROLSMA EM, DHONUKSHE-RUTTEN RAM, VAN WIJNGAARDEN JP, VAN DER ZWALUW NL, VAN DER VELDE N, DE GROOT L. Dietary sources of vitamin b-12 and their association with vitamin b-12 status markers in healthy older adults in the B-PROOF study. Nutrients 2015; 7: 7781-7797.
  • HORVAT P, GARDINER J, KUBINOVA R, PAJAK A, TAMOSIUNAS A, SCHÖTTKER B et al. Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study. Exp Gerontol 2016; 76: 33-38.
  • NAVAS-CARRETERO S, CUERVO M, ABETE I, ZULET MA, MARTÍNEZ JA. Frequent consumption of selenium-enriched chicken meat by adults causes weight loss and maintains their antioxidant status. Biol Trace Elem Res 2011; 143: 8-19.
  • REES K, HARTLEY L, DAY C, FLOWERS N, CLARKE A, STRANGES S. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013; 1:CD009671.
  • FERNÁNDEZ-LLAMA P, CALERO F. ¿Cómo influye el consumo de sal en la presión arterial? Mecanismos etiopatogénicos asociados. Hipertens Riesgo Vasc 2017; 17: 1837-1889.
  • ORTEGA ANTA RM, JIMÉNEZ ORTEGA AI, PEREA SÁNCHEZ JM, CUADRADO SOTO E, LÓPEZ SOBALER AM. Pautas nutricionales en prevención y control de la hipertensión arterial. Nutr Hosp 20 16; 33: 347.
  • CRUJEIRAS AB, PARRA D, ABETE I, MARTINEZ JA. A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects. Free Radic Res 2007; 41: 498-506.
  • GARCIA-LAFUENTE A, GUILLAMON E, VILLARES A, ROSTAGNO MA, MARTINEZ JA. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009; 58: 537-552.
  • BIESALSKI HK. Polyphenols and inflammation: basic interactions. Curr Opin Clin Nutr Metab Care 2007; 10: 724-728.
  • POWER R, COEN RF, BEATTY S, MULCAHY R, MORAN R, STACK J et al. supplemental retinal carotenoids enhance memory in healthy individuals with low levels of macular pigment in a randomized, double-blind, placebo-controlled clinical trial. J Alzheimers Dis 2018; 61: 947-961.
  • GOTHAI S, GANESAN P, PARK SY, FAKURAZI S, CHOI DK, ARULSELVAN P. Natural phyto-bioactive compounds for the treatment of type 2 diabetes: inflammation as a target . Nutrients 2016; 4. doi: 10.3390/nu8080461.
  • MURILLO AG, FERNANDEZ ML. Potential of dietary non-provitamin a carotenoids in the prevention and treatment of diabetic microvascular complications. Adv Nutr 2016; 7: 14-24.
  • LUO X, SU P, ZHANG W. Advances in microalgae-derived phytosterols for functional food and pharmaceutical applications. Mar Drugs 2015; 13: 4231-4254.
  • CABRAL CE, SIMAS MR, TORRES K. Phytosterols in the treatment of hypercholesterolemia and prevention of cardiovascular diseases. Arq Bras Cardiol 2017; 109: 475-482.
  • DE OLIVEIRA BARBOSA ROSA C, ARAÚJO DOS SANTOS C, ISAURA ALVAREZ LEITE J, SILVA CALDAS AP, BRESSAN J. Impact of nutrients and food components on dyslipidemias: what is the evidence? Adv Nutr 2015; 6: 703-711.
  • University of California, Berkeley (USA), Max Planck Institute for Demographic Research (Germany). Human mortality database. http: www.mortality.org. Consultado el 16 de julio de 2018.
Fuente de los datos: Dialnet