Infiltración meníngea de linfoma linfoplasmocíticosíndrome de Bing-Neel
- Raquel Behar Lagares
- Carlos Lombardía González
- María Cruz Cárdenas Fernández
- Celina Benavente
ISSN: 1888-4008
Argitalpen urtea: 2017
Alea: 10
Zenbakia: 1
Orrialdeak: 49-54
Mota: Artikulua
Beste argitalpen batzuk: Revista del laboratorio clínico
Laburpena
Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma defined by a monoclonal proliferation of bone marrow infiltrating immunoglobulin M producing B lymphocytes. Neurological simptoms of Waldenström macroglobulinemia are mainly dominated by signs of hyperviscosity and autoimmune neuropathies mediated by immunoglobulin M. Neurological involvement secondary to the infiltration of IgM producing B lymphocytes, is defined as a Bing-Neel syndrome. This syndrome has a low prevalence and the clinical manifestations are variable. The case described is about a 76 year-old female with a history of Waldenström macroglobulinemia, who presents sudden neurological signs such as alteration of spoken language and clumsiness of the right hand. The clinical laboratory has a primary role in the diagnosis of Bing-Neel syndrome and monitoring of the treatment.