Stereoselective organic synthesis in water: Organocatalysis by proline and its derivatives
- Vinoth, Perumal
- Karuppasamy, Muthu
- Menéndez, J. Carlos
- Vachan, B.S.
- Sridharan, Vellaisamy
Editorial: Elsevier
ISBN: 978-0-12-819542-0
Año de publicación: 2020
Páginas: 191-229
Tipo: Capítulo de Libro
Resumen
Water is not flammable, has no smell, is nontoxic and is easily separated from the products of organic reactions. Furthermore, when used as a reaction medium it often enhances the rate and selectivities of many organic reactions or leads to alternative reaction modes. Due to these features, stereoselective organocatalysis in water has attracted much interest from synthetic chemists. We summarize in this chapter the main developments on stereoselective reactions performed in water and using proline or proline derivatives as catalysts. Reactions catalyzed by solid-supported proline derivatives are also discussed in detail.