Estudio morfológico de la neurocarcinogénesis experimental inducida por nitroso-ureas

  1. Mercedes Zurita
  2. Jesús Vaquero Crespo
  3. Santiago de Oya Otero
  4. Celia Bonilla
  5. C. Aguayo
Anales de la Real Academia Nacional de Farmacia

ISSN: 1697-4271 1697-428X

Datum der Publikation: 2008

Nummer: 2

Seiten: 257-282

Art: Artikel

Andere Publikationen in: Anales de la Real Academia Nacional de Farmacia


SCImago Journal Rank

  • Jahr 2008
  • Impact SJR der Zeitschrift: 0.134
  • Höchstes Quartil: Q3
  • Bereich: Pharmacology (medical) Quartil: Q3 Position im Bereich: 170/249
  • Bereich: Cell Biology Quartil: Q4 Position im Bereich: 218/243
  • Bereich: Molecular Biology Quartil: Q4 Position im Bereich: 307/346
  • Bereich: Pharmaceutical Science Quartil: Q4 Position im Bereich: 107/147


This work shows a revision of the chemical neurocarcinogenesis, with special reference to the Nervous System tumors induced by ethyl-nitrosourea in the Wistar rat. Prenatal administration of this carcinogen (50 mg/kg, day 17 of pregnancy) induces Nervous System tumors with histological features of malignant schwannomas or oligodendrogliomas. However, and independently of their morphology, the immunohistochemical and ultrastructural studies allow to classify to these tumors as undifferentiated malignant tumors, with tumor cells showing possible differentiation toward neuronal and glial phenotypes. Their biologic properties and their possible diagnosis in vivo, by means of Magnetic Resonance, make this neurocarcinogenesis model to be extraordinarily useful to value the effect of new drug treatments, applicable to human malignant brain tumors