Estudio morfológico de la neurocarcinogénesis experimental inducida por nitroso-ureas

  1. Mercedes Zurita
  2. Jesús Vaquero Crespo
  3. Santiago de Oya Otero
  4. Celia Bonilla
  5. C. Aguayo
Anales de la Real Academia Nacional de Farmacia

ISSN: 1697-4271 1697-428X

Year of publication: 2008

Issue: 2

Pages: 257-282

Type: Article

More publications in: Anales de la Real Academia Nacional de Farmacia


SCImago Journal Rank

  • Year 2008
  • SJR Journal Impact: 0.134
  • Best Quartile: Q3
  • Area: Pharmacology (medical) Quartile: Q3 Rank in area: 170/249
  • Area: Cell Biology Quartile: Q4 Rank in area: 218/243
  • Area: Molecular Biology Quartile: Q4 Rank in area: 307/346
  • Area: Pharmaceutical Science Quartile: Q4 Rank in area: 107/147


This work shows a revision of the chemical neurocarcinogenesis, with special reference to the Nervous System tumors induced by ethyl-nitrosourea in the Wistar rat. Prenatal administration of this carcinogen (50 mg/kg, day 17 of pregnancy) induces Nervous System tumors with histological features of malignant schwannomas or oligodendrogliomas. However, and independently of their morphology, the immunohistochemical and ultrastructural studies allow to classify to these tumors as undifferentiated malignant tumors, with tumor cells showing possible differentiation toward neuronal and glial phenotypes. Their biologic properties and their possible diagnosis in vivo, by means of Magnetic Resonance, make this neurocarcinogenesis model to be extraordinarily useful to value the effect of new drug treatments, applicable to human malignant brain tumors