Investigación original sobre la epiteliosis mamaria canina. Una amenaza de interés en la clínica oncológica de pequeños animales

  1. EDGAR GUILLERMO VALDIVIA LARA 1
  2. ÁNGELA ALONSO DÍEZ 1
  3. DANIEL ALONSO MIGUEL 1
  4. MARÍA SUÁREZ REDONDO 1
  5. PALOMA MARTA GARCÍA FERNÁNDEZ 1
  6. GUSTAVO ORTIZ DÍEZ 1
  7. DOLORES PÉREZ ALENZA 1
  8. LAURA PEÑA FERNÁNDEZ 1
  1. 1 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

Revista:
Anales de la Real Academia de Ciencias Veterinarias

Año de publicación: 2020

Volumen: 28

Número: 28

Páginas: 13-42

Tipo: Artículo

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Resumen

La epiteliosis mamaria canina es considerada una displasia que puede progresar a carcinoma. El objetivo de este trabajo fue evaluar la frecuencia e importancia de la epiteliosis. En este estudio prospectivo se incluyeron perras con tumores mamarios sometidas a mastectomía total. Se realizaron estudios clínicos, patológicos e inmunohistoquímicos (AE1/AE3, CK14, p63, vimentina, calponina, HER-2, RE y RP). Se ana-lizaron estadísticamente variables epidemiológicas, clínicas y anatomo-patológicas. En total se incluyeron 66 perras con mastectomía unilateral (n=50) o bilateral (n=16) y 82 cadenas mamarias completas con 102 neo-plasias mamarias malignas. Se diagnosticó epiteliosis en 38/66 pacientes (57,6%), sobre todo de edad avanzada (p=0,02). En relación con los tu-mores malignos, la epiteliosis se encontró en la misma mama (15,8%), en la mama adyacente (5,3%), distante (15,8%), o adyacente y distante (63,2%). El 43,8% de las perras con mastectomía bilateral, tuvo epitelio-sis en ambas cadenas mamarias. El número y extensión de epiteliosis se asoció a la presencia de neoplasias malignas (p=0,031) y la metástasis a linfonódulos (p=0,003). Las perras con tumores malignos frecuente-mente tuvieron epiteliosis en mamas diferentes a la del tumor (p=0,0008). Las células origen de la epiteliosis son de inmunofenotipo epitelial basal (AE1/AE3+, CK14+, p63-, vimentina-, calponina-) triple negativo (HER-2-, RE- y PR-) lo que indica un mal pronóstico. La epi-teliosis es una lesión multifocal, sin cambios macroscópicos, que puede tener una gran extensión en la cadena mamaria de perras con neoplasias mamarias malignas. Debe ser tenida en cuenta en el planteamiento qui-rúrgico, ya que puede ser responsable del desarrollo de nuevos tumores mamarios malignos en mamas no operadas

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