Inmunoregulación en trasplante renal por células mieloides supresoras y células B reguladoras
- Utrero Rico, Alberto
- Estela Paz Artal Doktormutter
Universität der Verteidigung: Universidad Complutense de Madrid
Fecha de defensa: 12 von November von 2021
- Eduardo Martínez Naves Präsident
- M. Jose Recio Hoyas Sekretär/in
- José María Portolés Pérez Vocal
- Carlos Jiménez Martín Vocal
- Jorge Monserrat Sanz Vocal
Art: Dissertation
Zusammenfassung
Kidney transplantation is the best therapeutic option for patients with end‐stage renal disease (ESRD). Despite the improvement in results has been mostly possible thanks to the use of immunosuppressive drugs which avoid immune response against the allograft, rejections still happen, the long‐term graft survival remains suboptimal,and drug‐induced immunesuppression associated with complications such as infections and cancer. This makes it necessary to search for new non‐invasive biomarkers that predict graft rejection and deterioration, as well as other complications. Recently, minority cell populations with powerful immmunoregulatory capacities have emerged which could play an important role in graft tolerance. These populations include the monocytic myeloid derived suppressor cells (M‐MDSC), which have potent immunosuppressive effects on the immune responses, and regulatory B lymphocytes (IL10+Breg), which can produce IL10 and inhibit the effector function of T lymphocytes...