Inmunoregulación en trasplante renal por células mieloides supresoras y células B reguladoras

Resumo

Kidney transplantation is the best therapeutic option for patients with end‐stage renal disease (ESRD). Despite the improvement in results has been mostly possible thanks to the use of immunosuppressive drugs which avoid immune response against the allograft, rejections still happen, the long‐term graft survival remains suboptimal,and drug‐induced immunesuppression associated with complications such as infections and cancer. This makes it necessary to search for new non‐invasive biomarkers that predict graft rejection and deterioration, as well as other complications. Recently, minority cell populations with powerful immmunoregulatory capacities have emerged which could play an important role in graft tolerance. These populations include the monocytic myeloid derived suppressor cells (M‐MDSC), which have potent immunosuppressive effects on the immune responses, and regulatory B lymphocytes (IL10+Breg), which can produce IL10 and inhibit the effector function of T lymphocytes...