Infección experimental por toxoplasma gondii en el primer, segundo y último tercio de gestación en ovejas. Respuesta lesional y distribución del parásito

  1. Castaño, P. 1
  2. Fuertes, M. 1
  3. Regidor-Cerrillo, J. 2
  4. González-Lanza, C. 1
  5. Moreno-Gonzalo, J. 2
  6. Ferre, I. 2
  7. Fernández, M. 1
  8. Ferreras, M.C. 1
  9. Ortega-Mora, L.M. 2
  10. Pérez, V. 1
  11. Benavides, J. 1
  12. Katzer, F.
  1. 1 Universidad de León
    info

    Universidad de León

    León, España

    ROR https://ror.org/02tzt0b78

  2. 2 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

Book:
Xl Congreso Nacional de la Sociedad Española de Ovinotecnia y Caprinotecnia (SEOC) XVL Congreso Internacional
  1. María Jesús Alcalde Aldea (coord.)
  2. Martín Rodríguez García (coord.)

Publisher: Universitat Politècnica de València

ISBN: 978-84-9048-398-5

Year of publication: 2015

Pages: 463-468

Congress: Sociedad Española de Ovinotecnia y Caprinotecnia (SEOC). Jornadas (11. 2015. Castellón)

Type: Conference paper

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Abstract

The relation between gestational age and foetal death risk in ovinetoxoplasmosis is already known, but the mechanisms involved areyet not clear, especially in sheep. In order to study these mechanisms,pregnant sheep of the same age and genetic background were orallydosed with 50 oocysts of T. gondii (M4 isolate) at days 40 (G1), 90 (G2)and 120 (G3) of gestation. In each group, four animals were culledon the second, third and fourth week post infection (wpi) in order toevaluate parasite distribution and loads and lesions in target organs.There were no significant differences between groups in either rectaltemperatures, with a peak temperature at days 6 and 7 pi, or serologicalmaternal antibody kinetics. Parasite DNA and lesions were found in theplacentomes and foetal viscera of sheep from G1 only at the fourth wpi.In G2, parasite was found from the third wpi, also in placenta and foetalviscera, increasing both at the fourth week, but lesions were only presentat the fourth wpi. These lesions were the most severe found in wholeexperiment. In G3, parasite DNA but also placental and foetal lesionswere found in the third wpi. Three out of four sheep from G3 abortedat this time. At the fourth wpi, parasite burden in G3 foetal viscera waslower than those on G1 and G2. These results suggest that the periodof gestation influence the parasite multiplication and development oflesions in the placenta and foetus, and as a consequence the clinicalcourse in ovine toxoplasmosis.

Data source: Dialnet