Estudio de la amilina humana (hiapp) en la fisiopatología de la diabetes mellitus tipo 2 y su relación con las enfermedades neurodegenerativas

Abstract

Type 2 diabetes mellitus is a worldwide metabolic disease which is more prevalent in aged population (International Diabetes Federation, 2021). This disease is characterized by the onset of an insulin resistance that triggers a defect in insulin secretion and consequently, a chronic hyperglycemia status. The development of type 2 diabetes depends on the efficacy of the compensatory mechanism displayed by pancreatic β cells; this mechanism consists of an increase of β cell mass by hyperplasia and hypertrophy in response to an augmented demand of insulin (Stumvoll, Goldsteinand Van Haeften, 2005). Human amylin (hIAPP) is a hormone synthesized and secreted together with insulin in response to glucose, which aminoacidic sequence lacks residues capable of impede β-amyloid structures formation when this protein is misfolded. Due to this feature, human amylin is one of the causative factors of pancreatic β cell failure and type 2 diabetes mellitus onset (Westermark, Anderssonand Westermark, 2011)...