Autofagia un sistema celular de limpieza clave para la salud. Una visita al Premio Nobel de Fisiología o Medicina de 2016

  1. Macho-González, Adrián
  2. Sanchez Muniz, Francisco J 1
  1. 1 Académico de Número de la Real Academia Nacional de Farmacia. Departamento de Nutrición. Facultad de Farmacia, Universidad Complutense de Madrid (España)
Revista:
Journal of Negative and No Positive Results: JONNPR

ISSN: 2529-850X

Any de publicació: 2023

Títol de l'exemplar: Vol. 8 Núm. 1 (2023): JONNPR

Volum: 8

Número: 1

Pàgines: 417-439

Tipus: Article

DOI: 10.19230/JONNPR.4912 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Altres publicacions en: Journal of Negative and No Positive Results: JONNPR

Resum

Introduction. In 2016, the Karolinska Institute awarded Yoshinori Ohsumi the Nobel Prize in Physiology and Medicine for his studies on autophagy. Subsequently, many investigations have demonstrated the role of this process in health. Methods. Three aspects are reviewed: a) the information given by the Nobel Committee on the laureate’s research; b) the molecular mechanisms involved in autophagy; and c) the relationship between autophagy and health. Results. The most relevant aspects of autophagy research are presented, from De Duve's research with lysosomes to some relevant molecular details. Ohsumi's biographical data and aspects of his research that led to the Nobel are discussed; also, the characteristics of the three types of autophagy: macrophagy, microphagy and chaperone-dependent. Autophagy is highly dependent on nutritional status, stress, and the expression of certain genes, particularly the so-called autophagy-related genes (ATG). Alterations in the expression or the existence of polymorphisms in ATG cause significant changes in the formation of autophagosomes. The importance in health and some very prevalent pathologies of the recycling of whole cells and their isolated components is explained, as well as the role of the interaction of some drugs in the autophagic function. Conclusion. Autophagy is a very common cellular process, highly dependent on nutritional status and ATG expression and polymorphisms. It is determinant in maturation, development, and health, and participates in a relevant way in aging and in the prevention of degenerative diseases.

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Fuente de los datos: Dialnet