Structure-guided tuning of a selectivity switch towards ribonucleosides in Trypanosoma brucei purine nucleoside 2'-deoxyribosyltransferase
- Jon del Arco 1
- Alberto Mills 2
- Federico Gago 2
- Jesús Fernández-Lucas 1
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1
Universidad Europea de Madrid
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2
Universidad de Alcalá
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Proceedings:
BIOTRANS 2019
Year of publication: 2019
Congress: BIOTRANS 2019 celebrado del 7 al 11 de julio de 2019 en Groningen, The Netherlands. Organized by University of Groningen
Type: Conference Poster
Abstract
The use of nucleoside analogues (NAs) as therapeutic drugs is well established. Because of this,interest in stereoselective, sustainable and cheap synthetic methods keeps growing in thepharmaceutical industry.
Bibliographic References
- 1 Fresco-Taboada, A., de la Mata, I., Arroyo, M., Fernández-Lucas, J. (2013). New insights on nucleoside 2′- deoxyribosyltransferases: a versatile biocatalyst for one-pot one-step synthesis of nucleoside analogs. Appl. Microbiol. Biotechnol., 97(9): 3773-3785.
- 2 Pérez, E., Sánchez‐Murcia, P. A., Jordaan, J., Blanco, M. D., Mancheño, J. M., Gago, F., Fernández‐Lucas, J. (2018). Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2’‐ DeoxyribosylTransferase from Trypanosoma brucei. ChemCatChem., 10(19): 4406-4416.
- 3 Crespo, N., Sánchez-Murcia, P. A., Gago, F., Cejudo-Sanches, J., Galmes, M. A., Fernández-Lucas, J., Mancheño, J. M. (2017). 2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases. Appl. Microbiol. Biotechnol., 101(19): 7187-7200.