Structure-guided tuning of a selectivity switch towards ribonucleosides in Trypanosoma brucei purine nucleoside 2'-deoxyribosyltransferase

  1. Jon del Arco 1
  2. Alberto Mills 2
  3. Federico Gago 2
  4. Jesús Fernández-Lucas 1
  1. 1 Universidad Europea de Madrid
    info

    Universidad Europea de Madrid

    Madrid, España

    ROR https://ror.org/04dp46240

  2. 2 Universidad de Alcalá
    info

    Universidad de Alcalá

    Alcalá de Henares, España

    ROR https://ror.org/04pmn0e78

Aktak:
BIOTRANS 2019

Argitalpen urtea: 2019

Biltzarra: BIOTRANS 2019 celebrado del 7 al 11 de julio de 2019 en Groningen, The Netherlands. Organized by University of Groningen

Mota: Biltzarraren Kartela

GOOGLE SCHOLAR lock_openSarbide irekia editor

Laburpena

The use of nucleoside analogues (NAs) as therapeutic drugs is well established. Because of this,interest in stereoselective, sustainable and cheap synthetic methods keeps growing in thepharmaceutical industry.

Erreferentzia bibliografikoak

  • 1 Fresco-Taboada, A., de la Mata, I., Arroyo, M., Fernández-Lucas, J. (2013). New insights on nucleoside 2′- deoxyribosyltransferases: a versatile biocatalyst for one-pot one-step synthesis of nucleoside analogs. Appl. Microbiol. Biotechnol., 97(9): 3773-3785.
  • 2 Pérez, E., Sánchez‐Murcia, P. A., Jordaan, J., Blanco, M. D., Mancheño, J. M., Gago, F., Fernández‐Lucas, J. (2018). Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2’‐ DeoxyribosylTransferase from Trypanosoma brucei. ChemCatChem., 10(19): 4406-4416.
  • 3 Crespo, N., Sánchez-Murcia, P. A., Gago, F., Cejudo-Sanches, J., Galmes, M. A., Fernández-Lucas, J., Mancheño, J. M. (2017). 2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases. Appl. Microbiol. Biotechnol., 101(19): 7187-7200.