Enfermedades renales tubulointersticiales. Nefritis intersticial aguda

  1. Vega Cabrera, C. 1
  2. Rivas Becerra, B. 1
  3. García Fernández, E. 2
  4. Fernández Juárez, G. 1
  1. 1 Servicio de Nefrología, Hospital Universitario La Paz, Madrid, España
  2. 2 Servicio de Anatomía Patológica, Hospital Universitario La Paz, Madrid, España
Revista:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Año de publicación: 2023

Título del ejemplar: Enfermedades nefrourinarias (III): Enfermedades renales tubulointersticiales: tubulopatías y enfermedad quística renal

Serie: 13

Número: 81

Páginas: 4765-4773

Tipo: Artículo

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Otras publicaciones en: Medicine: Programa de Formación Médica Continuada Acreditado

Resumen

La nefritis intersticial aguda (NIA) está caracterizada por un infiltrado inflamatorio, edema y tubulitis en el intersticio renal que habitualmente condiciona un deterioro agudo de la función renal. La NIA se refiere a la forma aguda de la enfermedad que presenta un rápido deterioro de la función renal, mientras que las formas crónicas tienen un curso más prolongado, con mayor fibrosis detectada mediante histología. Por lo tanto, el diagnóstico definitivo de ambas patologías es histológico, ya que en la actualidad no se dispone de marcadores no invasivos para su confirmación o exclusión. La incidencia exacta es muy difícil de establecer, pero oscila entre un 5%-27%, con un incremento progresivo de la incidencia principalmente en ancianos, lo que puede reflejar una mayor exposición de los pacientes de edad avanzada a fármacos y otros factores desencadenantes. Actualmente las causas de la NIA han cambiado drásticamente, siendo ahora los agentes farmacológicos la etiología más común (más del 75%).

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Fuente de los datos: Dialnet