Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144

  1. Ramírez, Cristina M. 1
  2. Rotllan, Noemi 1
  3. Vlassov, Alexander V. 1
  4. Dávalos, Alberto 1
  5. Li, Mu 1
  6. Goedeke, Leigh 1
  7. Aranda, Juan F. 1
  8. Cirera-Salinas, Daniel 1
  9. Araldi, Elisa 1
  10. Salerno, Alessandro 1
  11. Wanschel, Amarylis 1
  12. Zavadil, Jiri 1
  13. Castrillo, Antonio 1
  14. Kim, Jungsu 1
  15. Suárez, Yajaira 1
  16. Fernández-Hernando, Carlos 1
  1. 1 From the Leon H. Charney Division of Cardiology, Departments of Medicine and Cell Biology and the Marc and Ruti Bell Vascular Biology and Disease Program (C.M.R., N.R., A.D., L.G., J.F.A., D.C.-S., E.A., A.S., A.W., Y.S., C.F.-H.), Department of Pathology, New York University Center for Health Informatics and Bioinformatics (J.Z.), New York University School of Medicine, New York, New York; Life Technologies, Austin, Texas (A.V.V., M.L.); Instituto de Investigaciones Biomédicas “Alberto Sols,”...
Revista:
Circulation Research

ISSN: 0009-7330,  1524-4571

Año de publicación: 2013

Volumen: 112

Número: 12

Páginas: 1592-1601

Tipo: Artículo

DOI: 10.1161/CIRCRESAHA.112.300626 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Circulation Research

Resumen

Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Liver X nuclear receptors (LXRs) regulate the expression of the adenosine triphosphate–binding cassette (ABC) transporters, including adenosine triphosphate–binding cassette transporter A1 (ABCA1) and adenosine triphosphate–binding cassette transporter G1 (ABCG1). ABCA1 and ABCG1 facilitate the efflux of cholesterol from macrophages and regulate high-density lipoprotein (HDL) biogenesis. Increasing evidence supports the role of microRNA (miRNAs) in regulating cholesterol metabolism through ABC transporters.

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Información de financiación

Financiadores

  • National Institutes of Health United States
    • R01HL107953 and R01HL106063
    • R01HL105945
    • P30NS069329
  • Spanish Ministry of I+D (grant SAF2008-00057 and SAF2011-29244 to A. Castrillo) Spain
    • SAF2008-00057 and SAF2011-29244

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