MicroRNA modulation of lipid metabolism and oxidative stress in cardiometabolic diseases

  1. Aranda, Juan F. 1
  2. Madrigal-Matute, Julio 1
  3. Rotllan, Noemi 1
  4. Fernández-Hernando, Carlos 1
  1. 1 Department of Medicine and Department of Cell Biology, Leon H. Charney Division of Cardiology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
Revista:
Free Radical Biology and Medicine

ISSN: 0891-5849

Año de publicación: 2013

Volumen: 64

Páginas: 31-39

Tipo: Artículo

DOI: 10.1016/J.FREERADBIOMED.2013.07.014 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Free Radical Biology and Medicine

Resumen

The regulation of the metabolism of cholesterol has been one of the most studied biological processes since its first isolation from gallstones in 1784. High levels of plasma low-density lipoprotein (LDL) cholesterol and reduced levels of plasma high-density lipoprotein (HDL) cholesterol are widely recognized as major risk factors of cardiovascular disease. An imbalance in the production of reactive oxygen species can oxidize LDL particles, increasing the levels of the highly proatherogenic oxidized LDL. Furthermore, under pathological scenarios, numerous molecules can function as pro-oxidants, such as iron or (high levels of) glucose. In addition to the classical mechanisms regulating lipid homeostasis, recent studies have demonstrated the important role of microRNAs (miRNAs) as regulators of lipoprotein metabolism, oxidative derivatives of lipoprotein, and redox balance. Here, we summarize recent findings in the field, highlighting the contributions of some miRNAs to lipid- and oxidative-associated pathologies. We also discuss how therapeutic intervention of miRNAs may be a promising strategy to decrease LDL, increase HDL, and ameliorate lipid- and oxidative-related disorders, including atherosclerosis, nonalcoholic fatty liver disease, and metabolic syndrome.

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Referencias bibliográficas

  • Bartel, (2009), Cell, 136, pp. 215, 10.1016/j.cell.2009.01.002
  • Voinnet, (2009), Cell, 136, pp. 669, 10.1016/j.cell.2009.01.046
  • Krol, (2010), Nat. Rev. Genet., 11, pp. 597, 10.1038/nrg2843
  • Carthew, (2009), Cell, 136, pp. 642, 10.1016/j.cell.2009.01.035
  • Heimberg, (2008), Proc. Natl. Acad. Sci. USA, 105, pp. 2946, 10.1073/pnas.0712259105
  • Gregory, (2004), Nature, 432, pp. 235, 10.1038/nature03120
  • Davis, (2011), Development, 138, pp. 127, 10.1242/dev.053637
  • Zhang, (2002), EMBO J., 21, pp. 5875, 10.1093/emboj/cdf582
  • Esteller, (2011), Nat. Rev. Genet., 12, pp. 861, 10.1038/nrg3074
  • Fernandez, (2004), Exp. Cell Res., 300, pp. 109, 10.1016/j.yexcr.2004.06.029
  • Fernandez, (2005), J. Lipid Res., 46, pp. 920, 10.1194/jlr.M400407-JLR200
  • Lopez, (2006), Lancet, 367, pp. 1747, 10.1016/S0140-6736(06)68770-9
  • Lagos-Quintana, (2002), Curr. Biol., 12, pp. 735, 10.1016/S0960-9822(02)00809-6
  • Chang, (2004), RNA Biol., 1, pp. 106, 10.4161/rna.1.2.1066
  • Krutzfeldt, (2005), Nature, 438, pp. 685, 10.1038/nature04303
  • Elmen, (2008), Nucleic Acids Res, 36, pp. 1153, 10.1093/nar/gkm1113
  • Tsai, (2012), J. Clin. Invest., 122, pp. 2884, 10.1172/JCI63455
  • Hsu, (2012), J. Clin. Invest., 122, pp. 2871, 10.1172/JCI63539
  • Rayner, (2011), J Clin Invest., 121, pp. :2921, 10.1172/JCI57275
  • Marquart, (2010), Proc. Natl. Acad. Sci. USA, 107, pp. 12228, 10.1073/pnas.1005191107
  • Najafi-Shoushtari, (2010), Science, 328, pp. 1566, 10.1126/science.1189123
  • Horie, (2010), Proc. Natl. Acad. Sci. USA, 107, pp. 17321, 10.1073/pnas.1008499107
  • Marquart, (2013), Arterioscler Thromb Vasc Biol., 33, pp. 455, 10.1161/ATVBAHA.112.300639
  • Li, T.; Francl, J.M.; Boehme S.; and Chiang, J.Y.; Regulation of cholesterol and bile acid homeostasis by the CYP7A1/SREBP2/miR-33a axis, Hepatology 2013, 10.1002/hep.26427
  • Davalos, (2011), Proc. Natl. Acad. Sci. USA, 108, pp. 9232, 10.1073/pnas.1102281108
  • Gerin, (2010), J. Biol. Chem., 285, pp. 33652, 10.1074/jbc.M110.152090
  • Ramirez, (2013), Mol. Cell. Biol., 33, pp. 2891, 10.1128/MCB.00016-13
  • Goedeke, (2013), Mol. Cell. Biol., 33, pp. 2339, 10.1128/MCB.01714-12
  • Ho, (2011), FASEB J, 25, pp. 1758, 10.1096/fj.10-179267
  • Rotllan, (2013), Arterioscler. Thromb. Vasc. Biol., 33, 10.1161/ATVBAHA.113.301732
  • Horie, (2012), J. Am. Heart Assoc., 1, pp. e003376, 10.1161/JAHA.112.003376
  • Ramirez, (2011), Arterioscler. Thromb. Vasc. Biol., 31, pp. 2707, 10.1161/ATVBAHA.111.232066
  • Kim, (2012), Exp. Neurol., 235, pp. 476, 10.1016/j.expneurol.2011.11.010
  • Ramirez, (2013), Circ. Res., 112, pp. 1592, 10.1161/CIRCRESAHA.112.300626
  • de Aguiar Vallim, (2013), Circ. Res., 112, pp. 1602, 10.1161/CIRCRESAHA.112.300648
  • Acton, (1996), Science, 271, pp. 518, 10.1126/science.271.5248.518
  • Azhar, (1998), J. Lipid Res, 39, pp. 1616, 10.1016/S0022-2275(20)32191-X
  • Landschulz, (1996), J. Clin. Invest., 98, pp. 984, 10.1172/JCI118883
  • Hu, (2012), Mol. Cell. Biol., 32, pp. 5035, 10.1128/MCB.01002-12
  • Wang, (2013), Mol. Cell Biol., 33, pp. 1956, 10.1128/MCB.01580-12
  • Zelcer, (2006), J. Clin. Invest., 116, pp. 607, 10.1172/JCI27883
  • Cha, (2007), J. Biol. Chem, 282, pp. 743, 10.1074/jbc.M605023200
  • Zhong, (2013), Cell. Signalling, 25, pp. 1429, 10.1016/j.cellsig.2013.03.003
  • Zhong, (2013), Lipids Health Dis., 12, pp. 32, 10.1186/1476-511X-12-32
  • Esau, (2004), J. Biol. Chem., 279, pp. 52361, 10.1074/jbc.C400438200
  • Bork, (2011), J. Cell Physiol., 226, pp. 2226, 10.1002/jcp.22557
  • Gerin, (2010), Am. J. Physiol. Endocrinol. Metab., 299, pp. E198, 10.1152/ajpendo.00179.2010
  • Vickers, (2013), Hepatology, 57, pp. 533, 10.1002/hep.25846
  • Lee, (2011), Mol. Cell. Biol., 31, pp. 626, 10.1128/MCB.00894-10
  • Bidzhekov, (2012), Thromb. Haemostasis, 107, pp. 619, 10.1160/TH11-09-0607
  • Raitoharju, (2011), Atherosclerosis, 219, pp. 211, 10.1016/j.atherosclerosis.2011.07.020
  • Cipollone, (2011), Stroke, 42, pp. 2556, 10.1161/STROKEAHA.110.597575
  • Wang, (2010), BMC Genomics, 11, pp. 163, 10.1186/1471-2164-11-163
  • Williams, (1995), Arterioscler. Thromb. Vasc. Biol., 15, pp. 551, 10.1161/01.ATV.15.5.551
  • Heinecke, (1998), Atherosclerosis, 141, pp. 1, 10.1016/S0021-9150(98)00173-7
  • Li, (2010), J. Hypertens., 28, pp. 1646, 10.1097/HJH.0b013e32833a4922
  • Yanagisawa, (1988), Nature, 332, pp. 411, 10.1038/332411a0
  • Qin, (2011), Biochem. Biophys. Res. Commun., 410, pp. 127, 10.1016/j.bbrc.2011.05.118
  • Qin, (2012), BMB Rep, 45, pp. 464, 10.5483/BMBRep.2012.45.8.033
  • Suarez, (2007), Circ. Res., 100, pp. 1164, 10.1161/01.RES.0000265065.26744.17
  • Wu, (2011), Circulation, 124, pp. 633, 10.1161/CIRCULATIONAHA.110.005108
  • Weber, (2010), Biochem. Biophys. Res. Commun., 393, pp. 643, 10.1016/j.bbrc.2010.02.045
  • Ito, (2010), Biochem. Biophys. Res. Commun., 398, pp. 735, 10.1016/j.bbrc.2010.07.012
  • Zhao, (2010), Am. J. Physiol. Endocrinol. Metab., 299, pp. E110, 10.1152/ajpendo.00192.2010
  • Menghini, (2009), Circulation, 120, pp. 1524, 10.1161/CIRCULATIONAHA.109.864629
  • Chen, Z.; Shentu, T.P.; Wen, L.; Johnson, D.A.; and Shyy, J.Y.; Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium, Antioxid. Redox Signaling, (in press)
  • Vidal, (1998), Eur. J. Biochem, 252, pp. 378, 10.1046/j.1432-1327.1998.2520378.x
  • Tabas, (2007), Circulation, 116, pp. 1832, 10.1161/CIRCULATIONAHA.106.676890
  • Ni, (2011), Am. J. Physiol. Heart Circ. Physiol, 300, pp. H1762, 10.1152/ajpheart.00829.2010
  • Zhou, (2011), Proc. Natl. Acad. Sci. USA, 108, pp. 10355, 10.1073/pnas.1107052108
  • Fang, (2012), Arterioscler. Thromb. Vasc. Biol., 32, pp. 979, 10.1161/ATVBAHA.111.244053
  • Chen, (2009), Cardiovasc. Res., 83, pp. 131, 10.1093/cvr/cvp121
  • Yang, (2011), FEBS Lett., 585, pp. 854, 10.1016/j.febslet.2011.02.009
  • Thulin, (2013), Int. J. Mol. Med., 31, pp. 1003, 10.3892/ijmm.2013.1311
  • Thulasingam, (2011), Mol. Cell. Biochem., 352, pp. 181, 10.1007/s11010-011-0752-2
  • Rong, (2003), Proc. Natl. Acad. Sci. USA, 100, pp. 13531, 10.1073/pnas.1735526100
  • Lacolley, (2012), Cardiovasc. Res., 95, pp. 194, 10.1093/cvr/cvs135
  • Fernandez-Ortiz, (1994), J. Am. Coll. Cardiol., 23, pp. 1562, 10.1016/0735-1097(94)90657-2
  • Sun, (2011), EMBO Rep., 12, pp. 56, 10.1038/embor.2010.172
  • Chen, (2012), Atherosclerosis, 222, pp. 314, 10.1016/j.atherosclerosis.2012.01.020
  • Lin, (2009), J. Biol. Chem., 284, pp. 7903, 10.1074/jbc.M806920200
  • Sawamura, (1997), Nature, 386, pp. 73, 10.1038/386073a0
  • Sun, (2011), Fundam. Clin. Pharmacol, 25, pp. 572, 10.1111/j.1472-8206.2010.00885.x
  • Ding, (2012), Exp. Biol. Med. (Maywood), 237, pp. 1093, 10.1258/ebm.2012.012082
  • Chen, (2011), FASEB J, 25, pp. 1718, 10.1096/fj.10-174904
  • Boon, (2011), Circ. Res., 109, pp. 1115, 10.1161/CIRCRESAHA.111.255737
  • Chan, (2009), Cell Metab., 10, pp. 273, 10.1016/j.cmet.2009.08.015
  • Favaro, (2010), PLoS One, 5, pp. e10345, 10.1371/journal.pone.0010345
  • Castoldi, (2011), J. Clin. Invest., 121, pp. 1386, 10.1172/JCI44883
  • Shan, (2007), Gastroenterology, 133, pp. 1166, 10.1053/j.gastro.2007.08.002
  • Martin-Ventura, (2012), Thromb. Haemostasis, 108, pp. 435, 10.1160/TH12-04-0248
  • Bastida, (1984), Blood, 64, pp. 177, 10.1182/blood.V64.1.177.177
  • Chen, (2012), Trends Cell Biol., 22, pp. 125, 10.1016/j.tcb.2011.12.001
  • Creemers, (2012), Circ. Res., 110, pp. 483, 10.1161/CIRCRESAHA.111.247452
  • Vickers, (2011), Nat. Cell Biol., 13, pp. 423, 10.1038/ncb2210
  • Arroyo, (2011), Proc. Natl. Acad. Sci. USA, 108, pp. 5003, 10.1073/pnas.1019055108
  • Fichtlscherer, (2010), Circ. Res., 107, pp. 677, 10.1161/CIRCRESAHA.109.215566
  • Tan, (2009), PLoS One, 4, pp. e7689, 10.1371/journal.pone.0007689
  • Fichtlscherer, (2011), Arterioscler. Thromb. Vasc. Biol., 31, pp. 2383, 10.1161/ATVBAHA.111.226696
  • McManus, (2011), Circulation, 124, pp. 1908, 10.1161/CIRCULATIONAHA.111.062117
  • Sun, (2012), Thromb. J, 10, pp. 16, 10.1186/1477-9560-10-16
  • Kosaka, (2010), J. Biol. Chem., 285, pp. 17442, 10.1074/jbc.M110.107821
  • Zhang, (2010), Mol. Cell, 39, pp. 133, 10.1016/j.molcel.2010.06.010
  • Zhou, (2013), Circ. Res., 113, pp. 40, 10.1161/CIRCRESAHA.113.280883
  • Hergenreider, (2012), Nat. Cell Biol., 14, pp. 249, 10.1038/ncb2441