Associations between Vitamin D Receptor (VDR) Polymorphisms and Gut Microbiota in a Spanish Population Sample

  1. Rocío González Soltero 3
  2. Carlo Bressa 1
  3. Mariangela Tabone 5
  4. Sara Clemente 5
  5. Mar Larrosa 4
  6. María Bailén 2
  1. 1 Department of Biomedicine, Universidad Francisco de Vitoria, 28223 Madrid, Spain
  2. 2 Preventive Medicine and Public Health and Microbiology Center, Faculty of Medicine, University Autónoma of Madrid, 28049 Madrid, Spain
  3. 3 Department of Biosciences, European University of Madrid, 28670 Madrid, Spain
  4. 4 Nutrition and Food Sciences Department, Faculty of Pharmacy, University Complutense of Madrid, 28040 Madrid, Spain
  5. 5 Pre-Clinical Dentistry Department, European University of Madrid, 28670 Madrid, Spain
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Actas:
Biology and Life Sciences Forum

Editorial: MDPI

ISSN: 2673-9976

Año de publicación: 2023

Volumen: 29

Número: x

Congreso: 3rd International Electronic Conference on Nutrients (IECN 2023), Online | 1–15 November 2023

Tipo: Aportación congreso

DOI: 10.3390/IECN2023-15530 GOOGLE SCHOLAR lock_openAcceso abierto editor

Resumen

This study examined the association between genetic variations in the Vitamin D Receptor (VDR) gene and the composition of gut microbiota in a Spanish population. The VDR gene plays a role in mediating the effects of vitamin D on gut microbiota composition. We analyzed 87 healthy participants from the Spanish Caucasian population and found that the genetic variations were in Hardy–Weinberg equilibrium. Through metataxonomic sequencing, we identified that the GG genotype from the VDR polymorphism rs731236 seems to be associated with the opportunistic genus Solobacterium, indicating that genetic variations may influence the composition of gut microbiota.

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Información de financiación

This research was funded by Universidad Europea de Madrid, grant number 2018/UEM04.

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