Neurotransmisión y neurorreparación
University of St Andrews
Saint Andrews, Reino UnidoPublikationen in Zusammenarbeit mit Forschern von University of St Andrews (11)
2020
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Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents
Drug Development Research, Vol. 81, Núm. 2, pp. 215-231
2018
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Evidence for a cyanine link between propargylamine drugs and monoamine oxidase clarifies the inactivation mechanism
Frontiers in Chemistry, Vol. 6, Núm. MAY
2017
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Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine
ACS Chemical Neuroscience, Vol. 8, Núm. 5, pp. 1026-1035
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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
Angewandte Chemie - International Edition, Vol. 56, Núm. 41, pp. 12765-12769
2016
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ASS234, as a new multi-target directed propargylamine for Alzheimer's disease therapy
Frontiers in Neuroscience, Vol. 10, Núm. JUN
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Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
ChemMedChem, pp. 1264-1269
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Multi-target directed donepezil-like ligands for Alzheimer's disease
Frontiers in Neuroscience, Vol. 10, Núm. MAY
2015
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Predicting targets of compounds against neurological diseases using cheminformatic methodology
Journal of Computer-Aided Molecular Design, Vol. 29, Núm. 2, pp. 183-198
2014
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Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies
Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1844, Núm. 2, pp. 389-397
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Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease
Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1844, Núm. 6, pp. 1104-1110
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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
Journal of Medicinal Chemistry, Vol. 57, Núm. 24, pp. 10455-10463