Publicaciones en colaboración con investigadores/as de Instituto de Química Médica (17)

2015

  1. Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids

    ChemMedChem, Vol. 10, Núm. 3, pp. 523-539

2014

  1. ITH12410/SC058: A new neuroprotective compound with potential in the treatment of Alzheimer's disease

    ACS Chemical Neuroscience, Vol. 5, Núm. 9, pp. 770-775

  2. N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

    Journal of Medicinal Chemistry, Vol. 57, Núm. 24, pp. 10455-10463

2013

  1. Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

    Current Alzheimer Research, Vol. 10, Núm. 8, pp. 797-808

  2. PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice

    ACS Chemical Neuroscience, Vol. 4, Núm. 9, pp. 1267-1277

  3. Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 67, pp. 64-74

  4. Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-β-induced neurotoxicity

    ACS Chemical Neuroscience, Vol. 4, Núm. 4, pp. 547-565

2012

  1. Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling

    European Journal of Medicinal Chemistry, Vol. 57, pp. 296-301

  2. Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 54, pp. 750-763

  3. α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: Synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties

    Journal of Medicinal Chemistry, Vol. 55, Núm. 1, pp. 153-168

2011

  1. N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 6, pp. 2224-2235

2009

  1. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease

    Journal of Medicinal Chemistry, Vol. 52, Núm. 9, pp. 2724-2732

2004

  1. Naturally occurring cyclohexane epoxides: Sources, biological activities and synthesis

    Chemical Reviews, Vol. 104, Núm. 6, pp. 2857-2899

  2. One or more =CH, =CC, and/or C=C bond(s) formed by rearrangement

    Comprehensive Organic Functional Group Transformations II (Elsevier Ltd.), pp. 797-888

2003

  1. Naturally occurring diazo compounds: The kinamycins

    Current Organic Chemistry, Vol. 7, Núm. 14, pp. 1433-1442

1999

  1. 1,3-Dipolar cycloaddition of 3-azido-3-deoxy-1,2:5,6-di-O- isopropylidene-α-D-glucofuranose and C60

    Journal of Chemical Research - Part S, pp. 680-681

1994

  1. 5,6-Dihydro-1H, 4H-pyrazolo[4,3-f]pyrrolo[1,2-a][1,4]diazepines. Synthesis and pharmacological evaluation

    European Journal of Medicinal Chemistry, Vol. 29, Núm. 3, pp. 233-239