Publicaciones en colaboración con investigadores/as de Universidad Central de Las Villas (19)

2018

  1. Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines

    ChemMedChem, Vol. 13, Núm. 12, pp. 1246-1259

  2. Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening

    Future Medicinal Chemistry, Vol. 10, Núm. 8, pp. 863-878

2015

  1. Bond-based bilinear indices for computational discovery of novel trypanosomicidal drug-like compounds through virtual screening

    European Journal of Medicinal Chemistry, Vol. 96, pp. 238-244

  2. Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents

    European Journal of Medicinal Chemistry, Vol. 94, pp. 276-283

2014

  1. A sequential procedure for rapid and accurate identification of putative trichomonacidal agents

    Journal of Microbiological Methods, Vol. 105, pp. 162-167

  2. Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones

    Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 5, pp. 1568-1585

2012

  1. Identification In Silico and In Vitro of Novel Trypanosomicidal Drug-Like Compounds

    Chemical Biology and Drug Design, Vol. 80, Núm. 1, pp. 38-45

  2. Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug

    European Journal of Medicinal Chemistry, Vol. 58, pp. 214-227

  3. Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs

    Memorias do Instituto Oswaldo Cruz, Vol. 107, Núm. 5, pp. 637-643

2011

  1. Ligand-based discovery of novel trypanosomicidal drug-like compounds: In silico identification and experimental support

    European Journal of Medicinal Chemistry, Vol. 46, Núm. 8, pp. 3324-3330

2009

  1. Discovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors

    QSAR and Combinatorial Science, Vol. 28, Núm. 1, pp. 9-26

2008

  1. Bond-based linear indices in QSAR: Computational discovery of novel anti-trichomonal compounds

    Journal of Computer-Aided Molecular Design, Vol. 22, Núm. 8, pp. 523-540

  2. New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors

    Journal of Biomolecular Screening, Vol. 13, Núm. 8, pp. 785-794

  3. Saponinas esteroidales de la planta Agave brittoniana (Agavaceae) con actividad contra el parásito Trichomona vaginalis

    Revista de Biologia Tropical, Vol. 56, Núm. 4, pp. 1645-1652

2006

  1. New ligand-based approach for the discovery of antitrypanosomal compounds

    Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 7, pp. 1898-1904

  2. Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 19, pp. 6502-6524

2005

  1. A computer-based approach to the rational discovery of new trichomonacidal drugs by atom-type linear indices

    Current Drug Discovery Technologies, Vol. 2, Núm. 4, pp. 245-265

  2. A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: Outcomes of in silico studies supported by experimental results

    Bioorganic and Medicinal Chemistry Letters, Vol. 15, Núm. 17, pp. 3838-3843

  3. A novel non-stochastic quadratic fingerprints-based approach for the 'in silico' discovery of new antitrypanosomal compounds

    Bioorganic and Medicinal Chemistry, Vol. 13, Núm. 22, pp. 6264-6275